203186-01-0

Basic information

• Product Name: (4-BROMOPHENYL)[1-(TRIFLUOROACETYL)-4-PIPERIDINYL]METHANONE
• Synonyms: (4-BROMOPHENYL)[1-(TRIFLUOROACETYL)-4-PIPERIDINYL]METHANONE
• CAS NO: 203186-01-0
• Molecular Formula: C₁₄H₁₃BrF₃NO₂
• Molecular Weight: 364.1577296
• Mol File: 203186-01-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-BROMOPHENYL)[1-(TRIFLUOROACETYL)-4-PIPERIDINYL]METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BROMOPHENYL)[1-(TRIFLUOROACETYL)-4-PIPERIDINYL]METHANONE(203186-01-0)
• EPA Substance Registry System: (4-BROMOPHENYL)[1-(TRIFLUOROACETYL)-4-PIPERIDINYL]METHANONE(203186-01-0)

Safety Data

• Hazardous Substances Data: 203186-01-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(4-BROMOPHENYL)[1-(TRIFLUOROACETYL)-4-PIPERIDINYL]METHANONE is used as a building block in the synthesis of pharmaceuticals and other organic compounds, contributing to the development of new drugs and therapeutic agents.
Used in Chemical Research:
In the field of chemical research, (4-BROMOPHENYL)[1-(TRIFLUOROACETYL)-4-PIPERIDINYL]METHANONE serves as a reagent or intermediate in various chemical reactions, aiding in the advancement of scientific knowledge and the creation of novel chemical entities.
Used in Studying Pharmacological and Biological Properties:
Due to its unique structural features, (4-BROMOPHENYL)[1-(TRIFLUOROACETYL)-4-PIPERIDINYL]METHANONE is used in research to study its pharmacological and biological properties, which may lead to a better understanding of its potential applications in medicine and other fields.

Upstream product

• 126501-70-0 1-(2,2,2-trifluoroacetyl)piperidine-4-carboxylic acid 
• 108-86-1 bromobenzene 
• 126501-71-1 1-(2,2,2-trifluoroacetyl)piperidine-4-carbonyl chloride 
• 498-94-2 isonipecotic acid 

Downstream Products

• 439811-37-7 4-(4-bromobenzoyl)piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

PIPERIDINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS

Pharmaceutical compositions for the treatment of HIV are provided comprising compounds of formula (II) or a pharmaceutically acceptable salt or isomer thereof, in combination with specified antiviral agents.

Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity

We previously reported the discovery of 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1′-[(2,4-dimethyl-3 -pyridinyl)carbonyl]-4′-methyl-1,4′-bipipefidine N-oxide 1 (SCH 351125) as an orally bioavailable human CCR5 antagonist for the treatment of HIV-1 infec

Discovery of 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1′-[(2,4-dimethyl- 3pyridinyl)carbonyl]-4′-methyl-1,4′bipiperidine N-oxide (SCH 351125): An orally bioavailable human CCR5 antagonist for the treatment of HIV infection

Structure - activity studies on piperidino-piperidine 3 led to the discovery of SCH 351125 (1), a selective CCR5 antagonist with potent activity against RANTES binding (Ki=2 nM), which possesses subnanomolar activity in blocking viral entry and