20327-23-5

Basic information

• Product Name: 1-Cyclopropylpiperazine
• Synonyms: 1-Cyclopropylpiperazine;(Piperazin-1-yl)cyclopropane;N-cyclopropylpiperazine;Cyclopropyl piperazine;Piperazine,1-cyclopropyl-
• CAS NO: 20327-23-5
• Molecular Formula: C₇H₁₄N₂
• Molecular Weight: 126.2
• EINECS: 1312995-182-4
• Product Categories: Piperazines;Pyridines
• Mol File: 20327-23-5.mol

Chemical Properties

• Boiling Point: 43°C/7mm
• Flash Point: 89.2 °C
• Appearance: /
• Density: 1.047 g/cm³
• Vapor Pressure: 0.331mmHg at 25°C
• Refractive Index: 1.4804
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 9.23±0.10(Predicted)
• CAS DataBase Reference: 1-Cyclopropylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclopropylpiperazine(20327-23-5)
• EPA Substance Registry System: 1-Cyclopropylpiperazine(20327-23-5)

Safety Data

• Hazard Codes: Xi
• RIDADR: 3267
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 20327-23-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Cyclopropylpiperazine is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic effects. Its unique structure allows for the creation of compounds that can target specific biological pathways, enhancing the efficacy of medications.
Used in Agrochemical Industry:
1-Cyclopropylpiperazine is utilized as an intermediate in the production of agrochemicals, specifically in the synthesis of pesticides and other crop protection agents. Its incorporation into these compounds can lead to improved performance and selectivity, ensuring effective pest control while minimizing environmental impact.
Used in Organic Synthesis:
1-Cyclopropylpiperazine is employed as a building block in organic synthesis for its reactivity and capacity to participate in a variety of chemical reactions. This allows chemists to create a diverse range of organic compounds for use in various applications, from materials science to specialty chemicals.
Used in Medicinal Research:
In the field of medicinal research, 1-Cyclopropylpiperazine is used as a key component in the development of novel therapeutic agents. Its unique structural features enable the design of compounds with specific pharmacological properties, contributing to the advancement of treatments for various diseases and conditions.

InChI:InChI=1/C7H14N2/c1-2-7(1)9-5-3-8-4-6-9/h7-8H,1-6H2

Upstream product

• 159974-45-5 3-(2-Cyclopropylamino-ethyl)-oxazolidin-2-one 
• 77278-34-3 4-cyclopropylpiperazine-1-carboxylic acid tert-butyl ester 
• 110694-10-5 bis-(2-sulfooxy-ethyl)-amine 
• 765-30-0 Cyclopropylamine 

Downstream Products

• 1248588-66-0 1-benzyl-4-cyclopropyl-piperazine 
• 549510-57-8 4-Cyclopropylmethyl-piperazine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester 
• 477576-64-0 3-[1-[4-(4-Cyclopropylmethyl-piperazine-1-carbonyl)-3,5-dimethyl-1H-pyrrol-2-yl]-meth-(Z)-ylidene]-5-(2,6-dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one 
• 477576-63-9 3-[1-{4-[2-(4-Cyclopropyl-piperazin-1-yl)-2-oxo-ethyl]-3,5-dimethyl-1H-pyrrol-2-yl }-meth-(Z)-ylidene]-5-(2,6-dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one 
• 77278-34-3 4-cyclopropylpiperazine-1-carboxylic acid tert-butyl ester 
• 1035271-08-9 ethyl 4-(4-cyclopropylpiperazin-1-yl)benzoate 
• 1184298-24-5 5-chloro-thiophene-2-carboxylic acid [(S)-2-[3-(1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-2-methoxy-benzenesulfonylamino]-3-(4-cyclopropyl-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride 
• 1184298-14-3 5-chloro-thiophene-2-carboxylic acid [(S)-2-[3-(5-chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-2-methoxy-benzenesulfonylamino]-3-(4-cyclopropyl-piperazin-1-yl)-3-oxo-propyl]-amide hydrochloride 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF PIPERAZINYL AND DIAZEPANYL BENZAMIDE DERIVATIVES

The present invention is directed to a novel process for the preparation of piperazinyl and diazapanyl benzamide derivatives, useful for the treatment of disorders and conditions mediated by a histamine receptor, preferably the H3 receptor.

NOVEL COMPOUNDS

There is provided a compound of formula (I): or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.

1-Alkyl-4-acylpiperazines as a new class of imidazole-free histamine H 3 receptor antagonists

With the aim of identifying structurally novel, centrally acting histamine H3 antagonists, arrays of monoacyldiamines were screened. This led to the discovery of a series of 1-alkyl-4-acylpiperazines which were potent antagonists at the human histamine H3 receptor. The most potent amides had antagonist potencies in the subnanomolar range.

Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones

This invention relates to compounds of Formula I STR1 which are useful in association with a pharmaceutical carrier as antiatherosclerotic agents. In addition, various compounds of Formula I are useful inhibitors of cell proliferation.

Use of 2-Oxazolidinones As Latent Aziridine Equivalents. III. Preparation of N-Substituted Piperazines.

A number of N-aryl and N-alkyl substituted piperazines 1 were prepared from variously substituted 2-oxazolidinone derivatives 3.The method involved treatment of 3 with HBr in glacial acetic acid followed by heating the resulting ring-opened salts 5 in alcoholic solvent.The piperazines 1a-1q were isolated by crystallization in yields ranging from 23-91percent.

Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones

This invention relates to compounds of Formula I STR1 which are useful as antiatherosclerotic agents and inhibitors of cell proliferation for the treatment of proliferative diseases. In addition, various compounds of Formula I are useful inhibitors of platelet aggregation.

1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acids and antibacterial agents containing them

An antibacterial 1-cyclopropyl-6-fluoro-1,4- dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid of the formula STR1 in which R represents branched or straight-chain propyl or butyl which is optionally substituted by hydroxy or methoxy, unsubstituted tert.-butyl, 2-methylthioethyl, trifluoromethylthiomethyl, 2-trifluoromethylthioethyl, cycloalkyl with 3 to 6 carbon atoms, cycloalkenyl having 5 to 6 carbon atoms optionally substituted by hydroxyl, 1,1-dioxidotetrahydrothiophen-3-yl, cyclopropylmethyl, 1-phenethyl, furylmethyl, allyl or propargyl optionally substituted by phenyl and their pharmaceutically usable hydrates, acid addition salts, metal and guanidinium salts and prodrug forms.