- Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists
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A novel series of pyrazolo[1,5-a]pyrimidine derivatives was synthesized and evaluated as NPY Y1R antagonists. High binding affinity and selectivity were achieved with C3 trisubstituted aryl groups and C7 substituted 2-(tetrahydro-2H-pyran-4-ylamino)ethyla
- Griffith, David A.,Hargrove, Diane M.,Maurer, Tristan S.,Blum, Charles A.,De Lombaert, Stéphane,Inthavongsay, John K.,Klade, Lee E.,MacK, Christine M.,Rose, Colin R.,Sanders, Martin J.,Carpino, Philip A.
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scheme or table
p. 2641 - 2645
(2011/06/20)
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- Fused heterotricyclic compounds, process for preparing the compounds and drugs containing the same
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The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrat
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- SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES
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This invention relates to compounds of the formula wherein A, B, D, E K, I, G, R3 and R5 are defined as in the specification, and to the pharmaceutically acceptable salts of such compounds.
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