- Method for hydrogenolysis of halides
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The invention discloses a method for hydrogenolysis of halides. The invention discloses a preparation method of a compound represented by a formula I. The preparation method comprises the following step: in a polar aprotic solvent, zinc, H2O and a compound represented by a formula II are subjected to a reaction as shown in the specification, wherein X is halogen; Y is -CHRR or R; hydrogenin H2O exists in the form of natural abundance or non-natural abundance. According to the preparation method, halide hydrogenolysis can be simply, conveniently and efficiently achieved through a simple and mild reaction system, and good functional group compatibility and substrate universality are achieved.
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Paragraph 0232; 0290-0292
(2021/01/11)
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- Dehalogenative Deuteration of Unactivated Alkyl Halides Using D2O as the Deuterium Source
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The general dehalogenation of alkyl halides with zinc using D2O or H2O as a deuterium or hydrogen donor has been developed. The method provides an efficient and economic protocol for deuterium-labeled derivatives with a wide substrate scope under mild reaction conditions. Mechanistic studies indicated that a radical process is involved for the formation of organozinc intermediates. The facile hydrolysis of the organozinc intermediates provides the driving force for this transformation.
- Xia, Aiyou,Xie, Xin,Hu, Xiaoping,Xu, Wei,Liu, Yuanhong
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p. 13841 - 13857
(2019/10/17)
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- Synthesis of 1-Arylalk-2-enes and 1-Arylalkanes via Friedel-Crafts Alkylation with Allylic Alcohols Catalysed by an Acidic Clay
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Moderately activated benzenoid compounds undergo alkylation with allylic alcohols in the presence of acidic K10 clay to give almost exclusively 1-arylalk-2-enes by attack at the terminal position of the intermediate allyl cation; catalytic hydrogenation yields the corresponding 1-arylalkanes.
- Smith, Keith,Pollaud, Guy M
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p. 3519 - 3520
(2007/10/02)
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