3-Fluoroazetidinecarboxylic Acids and trans,trans- 3,4-Difluoroproline as Peptide Scaffolds: Inhibition of Pancreatic Cancer Cell Growth by a Fluoroazetidine Iminosugar
Reverse aldol opening renders amides of 3-hydroxyazetidinecarboxylic acids (3-OH-Aze) unstable above pH 8. Aze, found in sugar beet, is mis-incorporated for proline in peptides in humans and is associated with multiple sclerosis and teratogenesis. Aze-con
Liu, Zilei,Jenkinson, Sarah F.,Vermaas, Tom,Adachi, Isao,Wormald, Mark R.,Hata, Yukako,Kurashima, Yukiko,Kaji, Akira,Yu, Chu-Yi,Kato, Atsushi,Fleet, George W. J.