- Photocatalytic ?±-oxyamination of stable enolates, silyl enol ethers, and 2-oxoalkane phosphonic esters
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Fast ?±-oxyamination of stable enolates, silyl enol ethers, and in situ deprotonated dialkyl 2-oxoalkane phosphonates and diphenyl-2-oxoalkyl phosphine oxides was performed in the presence of [Ru(bpy)3]2+ (bpy = 2,2a?2-bipyridyl) as a photocatalyst, 2,2,6,6-tetramethylpiperidine nitroxide (TEMPO), and visible light. The key step was the light-induced one-electron oxidation of TEMPO into the 2,2,6,6-tetramethylpiperidine- 1-oxoammonium ion, which was nucleophilically attacked to yield ?±-functionalized carbonyl compounds. The reaction time was significantly reduced by the use of the microreactor flow technique.
- Schroll, Peter,K??nig, Burkhard
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supporting information
p. 309 - 313
(2015/03/03)
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