204512-95-8

Basic information

• Product Name: (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE
• Synonyms: (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE;(S)-3-aminotetrahydrofuran hydrochloride;(3S)-Tetrahydrofuran-3-aMine hydrochloride;(S)-3-AMinotetrahydrofuran, HCl;(3S)-oxolan-3-aMine hydrochloride;(3S)-Tetrahydro-3-furanaMine HCl;(S)-Tetrahydro-furan-3-ylamine hydrochloride;(S)-Tetrahydro-3-furylamine hydrochloride
• CAS NO: 204512-95-8
• Molecular Formula: C₄H₉NO*ClH
• Molecular Weight: 123.5813
• Mol File: 204512-95-8.mol

Chemical Properties

• Boiling Point: 173.5 °C at 760 mmHg
• Flash Point: 58.7 °C
• Appearance: /Solid
• Vapor Pressure: 1.09mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE(204512-95-8)
• EPA Substance Registry System: (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE(204512-95-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• Hazardous Substances Data: 204512-95-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE is used as a key intermediate in the synthesis of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) inhibitors. These inhibitors are of significant interest due to their potential role in treating various metabolic disorders, such as type 2 diabetes and obesity, by modulating the activity of the 11β-HSD1 enzyme. The enzyme plays a critical role in regulating glucocorticoid levels, which are linked to insulin sensitivity and glucose homeostasis.
In the development of 11β-HSD1 inhibitors, (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE contributes to the formation of the active pharmaceutical ingredient (API), which can then be formulated into drugs for clinical use. The synthesis of these inhibitors often involves multi-step organic reactions, with (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE being a pivotal component in constructing the final molecule.
The use of (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE in the pharmaceutical industry highlights its importance in drug discovery and development, particularly for conditions that require precise modulation of enzyme activity. As research into 11β-HSD1 inhibitors continues, the role of (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE as an intermediate is expected to grow, potentially leading to the discovery of new and more effective treatments for metabolic disorders.

InChI:InChI=1/C4H9NO.ClH/c5-4-1-2-6-3-4;/h4H,1-3,5H2;1H/t4-;/m0./s1

Upstream product

• 1070789-73-9 C₁₁H₁₅NO₃S 
• 152495-79-9 (S)-3-benzoylamino-tetrahydrofuran 

Downstream Products

• 1196509-67-7 C₃₂H₃₂F₂N₄O₆ 
• 1196509-58-6 3-(5-((1R,2S)-2-(2,2-difluoropropanamido)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propoxy)-1H-indazol-1-yl)-N-((S)-tetrahydrofuran-3-yl)benzamide 
• 1073973-23-5 (S)-4-bromo-2-fluoro-6-((tetrahydrofuran-3-yl)amino)benzonitrile 
• 1572515-83-3 (S)-2-fluoro-5-(N-(tetrahydrofuran-3-yl)sulfamoyl)benzoic acid 
• 1572515-41-3 (S)-3-(N-(tetrahydrofuran-3-yl)sulfamoyl)benzoic acid 
• 1359969-64-4 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-N-((S)-tetrahydrofuran-3-yl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxamide 

Relevant articles and documents

Expeditious novel routes to enantiopure 3-amino tetrahydrofuran hydrochloride

The synthesis of chemically and enantiomerically pure (S)-3-amino tetrahydrofuran hydrochloride starting from the natural amino acids, l-aspartic acid or l-methionine is described. The process involves no chromatography and can be easily carried out on a large scale. The enantiopurity of the final product was established by NMR and chiral HPLC methods.

Processes for the Manufacture of Chiral and Racemic Forms of 3-Aminotetrahydrofurans, Their Salts and Derivatives

A novel process for the synthesis of (S)-3-Amino-tetrahydrofuran and (R)-3-Amino-tetrahydrofuran is described. The process is applicable for substituted chiral-3-aminotetrahydrofuran derivatives.

N6 mono heterocyclic substituted adenosine derivatives

A substituted N 6 -oxa, thia, thioxa and azacycloalkyl substituted adenosine derivative and a method for using the composition as an A 1 heart adenosine receptor.