- Microwave-assisted debromination of α-bromoketones with triarylstibanes in water
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Several α-bromoarylketones were reacted with triarylstibanes under microwave irradiation in water to obtain the corresponding debrominated ketones. Under similar reaction conditions, 1,2-elimination of vic-dibromides in water afforded the corresponding E-olefins. This reaction is the first example of organoantimony compounds utilized for organic transformation in water.
- Murata, Yuki,Sugawara, Yoshiyuki,Matsumura, Mio,Kakusawa, Naoki,Yasuike, Shuji
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p. 1081 - 1084
(2017/11/17)
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- Efficient access to isoxazoles from alkenes
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The direct regioselective synthesis of 3,5-disubstituted isoxazoles was achieved in one reaction vessel through a sequence of reactions involving the net bromination of an electron-deficient alkene, in situ generation of a nitrile oxide, 1,3-dipolar cycloaddition, and loss of HBr from an intermediate 5,5-disubstituted bromoisoxazoline. This one-pot process enables the synthesis of 3,5-disubstituted isoxazoles directly from electron-deficient alkenes thereby negating the isolation of the 1,1-disubstituted bromoalkene alkyne surrogate. Georg Thieme Verlag Stuttgart.
- Xu, Jianping,Hamme II, Ashton T.
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p. 919 - 923
(2008/12/22)
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- Isoxazoles from 1,1-disubstituted bromoalkenes
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The regioselective synthesis of 3,5-disubstituted isoxazoles was achieved through the 1,3-dipolar cycloaddition of nitrile oxides with 1,1-disubstituted bromoalkenes. The substituted bromoalkenes function as alkyne synthons which were used to construct 5,
- Dadiboyena, Sureshbabu,Xu, Jianping,Hamme II, Ashton T.
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p. 1295 - 1298
(2007/10/03)
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- Oxidative degradation of arylfuro-1,2-oxazoles to arylnitriles by potassium permanganate
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Arylfuroisoxazolines are oxidatively degraded to arylnitriles by treatment with a mixture of potassium permanganate and sodium acetate in dry dioxane.
- Salgado-Zamora, Hector,Campos, Elena,Jimenez, Rogelio,Ruiz, Rosalba,Castaneda, Teresa,Turijan, Sara
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p. 209 - 212
(2007/10/03)
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- Synthesis and pharmacological characterization of new analogs of broxaterol
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A series of isoxazole derivatives structurally related to broxaterol 1 has been prepared and tested for their potency to β1 and β2 adrenergic receptors. At variance with broxaterol, none of the tested compounds displayed agonistic activity. The 3-isopropenyl derivative 5f is the most potent antagonist both in the trachea and atria preparations.
- De Amici,Conti,Dallanoce,Kassi,Castellano,Stefancich,De Micheli
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- In search of new chemical entities with spermicidal and anti-HIV activities
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Several compounds belonging to 2-isoxazolines (4,5a-c), isoxazoles (3,6a-c) and 1-amino-1-cycloalkyl-2-substituted phenyl ethanes (16-18,a-e) have been synthesised and found to possess spermicidal activity. Out of these a couple of compounds (5a and 6a) exhibit anti-HIV activity. (C) Elsevier Science Ltd.
- Srivastava, Seema,Bajpai, Lakshmi Kant,Batra, Sanjay,Bhaduri, Amiya P.,Maikhuri,Gupta, Gopal,Dhar
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p. 2607 - 2613
(2007/10/03)
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- 1,3-DIPOLAR CYCLOADDITION REACTIONS INVOLVING CAPTODATIVE OLEFINS
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A series of arylnitrile oxides (6a-e) were reacted with captodative olefins (4) to yield 5-acetyl-3-arylisoxazoles.No intermediate isoxazolines were formed, the olefins thus behaved as acetylene equivalents.A plausible explanation for the observed regiose
- Jimenez, Rogelio,Perez, Lucelia,Tamariz, Joaquin,Salgado, Hector
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p. 591 - 598
(2007/10/02)
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