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acetylaranotin is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

20485-01-2

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20485-01-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 20485-01-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,4,8 and 5 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 20485-01:
(7*2)+(6*0)+(5*4)+(4*8)+(3*5)+(2*0)+(1*1)=82
82 % 10 = 2
So 20485-01-2 is a valid CAS Registry Number.

20485-01-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Acetylaranotin

1.2 Other means of identification

Product number -
Other names LL-S-88-A

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:20485-01-2 SDS

20485-01-2Upstream product

20485-01-2Downstream Products

20485-01-2Relevant articles and documents

Antiviral agents. Chemical modifications of a disulfide antibiotic, acetylaranotin

Murdock

, p. 827 - 835 (1974)

The reactivity of the cyclic disulfide linkage in acetylaranotin was investigated. Novel insertion reactions with elemental sulfur and hydrogen cyanide gave a tetrasulfide and a dithiocarbamate. Cleavages with methanethiol and dimethyl disulfide gave a dithiol and a bis(methyl disulfide). In mice, the tetrasulfide and a trisulfide gave protection equivalent to that of acetylaranotin against a lethal respiratory virus, Coxsackie A 21. Carbethoxy derivatives were less active. Marginal activities of a trithiocarbonate and a monosulfide give the first indication that an S S linkage may not be an absolute requirement for antiviral activity in this family of compounds. In an enzyme inhibition assay against an RNA polymerase system from Coxsackie A 21 virus, several compounds were more than 1000 times more inhibitory toward the viral polymerase than they were toward the RNA polymerase of the uninfected host cells. An improved color test for detection of thiols is described.

Enantioselective total synthesis of (-)-acetylaranotin, a dihydrooxepine epidithiodiketopiperazine

Codelli, Julian A.,Puchlopek, Angela L. A.,Reisman, Sarah E.

, p. 1930 - 1933 (2012/03/11)

The first total synthesis of the dihydrooxepine-containing epidithiodiketopiperazine (ETP) (-)-acetylaranotin (1) is reported. The key steps of the synthesis include an enantioselective azomethine ylide (1,3)-dipolar cycloaddition reaction to set the absolute and relative stereochemistry, a rhodium-catalyzed cycloisomerization/chloride elimination sequence to generate the dihydrooxepine moiety, and a stereoretentive diketopiperazine sulfenylation to install the epidisulfide. This synthesis provides access to (-)-1 in 18 steps from inexpensive, commercially available starting materials. We anticipate that the approach described herein will serve as a general strategy for the synthesis of additional members of the dihydrooxepine ETP family.

Total synthesis of (-)-Acetylaranotin

Fujiwara, Hideto,Kurogi, Taichi,Okaya, Shun,Okano, Kentaro,Tokuyama, Hidetoshi

, p. 13062 - 13065 (2013/02/26)

Epidithiodiketopiperazines are an important class of natural products because of their unique structural and biological properties. Among them, acetylaranotin (1), SCH64874 (2), compound 3, emethallicin A (4), MPC1001 (5), and emestrin (6) feature a dihydrooxepine moiety fused to a pyrrolidine/ epidithiodiketopiperazine (Figure 1). They also display a range of intriguing biological activities, such as: inhibitory activity against viral RNA polymerase, antagonistic activity of epidermal growth factor receptor, potent antituberculous activity, inhibitory activity against histamine release, antiproliferative activity against DU145 human prostate cancer cell line, and antagonistic activity of chemokine receptor (CCR2). While numerous synthetic approaches were investigated, only a limited number of successful preparations of the characteristic dihydrooxepine ring have been reported. During the synthetic studies on MPC1001, Peng and Clive established a synthetic method for a pyrrolidinone-fused dihydrooxepine through tetrahydrooxepine formation followed by selenoxide elimination.

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