205046-59-9

Basic information

• Product Name: 5-Nitroquinoline-8-carbonitrile
• Synonyms: 5-Nitroquinoline-8-carbonitrile
• CAS NO: 205046-59-9
• Molecular Formula: C10H5N3O2
• Molecular Weight: 199.1656
• Mol File: 205046-59-9.mol

Chemical Properties

• Boiling Point: 422.8±35.0 °C(Predicted)
• Appearance: /
• Density: 1.43±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.40±0.29(Predicted)
• CAS DataBase Reference: 5-Nitroquinoline-8-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Nitroquinoline-8-carbonitrile(205046-59-9)
• EPA Substance Registry System: 5-Nitroquinoline-8-carbonitrile(205046-59-9)

Safety Data

• Hazardous Substances Data: 205046-59-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Nitroquinoline-8-carbonitrile is used as an intermediate in the production of various pharmaceuticals for its ability to be incorporated into the molecular structures of different drugs, enhancing their therapeutic properties.
Used in Agrochemical Industry:
5-Nitroquinoline-8-carbonitrile is used as a precursor in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural products to protect crops and improve yield.
Used in Dye Industry:
5-Nitroquinoline-8-carbonitrile is used as a component in the creation of dyes, providing a range of colors and properties for various applications, including textiles and other industrial processes.
Used in Organic Synthesis:
5-Nitroquinoline-8-carbonitrile is used as a reagent in the synthesis of various heterocyclic compounds, playing a key role in the formation of complex organic molecules for research and commercial purposes.
Used in Medicinal Chemistry Research:
5-Nitroquinoline-8-carbonitrile is used as a subject of interest in medicinal chemistry due to its potential biological and pharmacological activities, aiding in the discovery and development of new drugs and therapeutic agents.

Upstream product

• 139366-35-1 8-bromo-5-nitroquinoline 
• 83848-59-3 5-nitroquinoline-8-carboxylic acid 
• 64976-62-1 8-methyl-5-nitroquinoline 
• 611-32-5 8-methylquinoline 

Downstream Products

• 83848-59-3 5-nitroquinoline-8-carboxylic acid 
• 573758-03-9 5-amino-quinoline-8-carbonitrile 

Relevant articles and documents

Cathepsin B inhibitors: Further exploration of the nitroxoline core

Human cathepsin B is a cysteine protease with many house-keeping functions, such as intracellular proteolysis within lysosomes. Its increased activity and expression have been strongly associated with many pathological processes, including cancers. We present here the design and synthesis of novel derivatives of nitroxoline as inhibitors of cathepsin B. These were prepared either by omitting the pyridine part, or by modifying positions 2, 7, and 8 of nitroxoline. All compounds were evaluated for their ability to inhibit endopeptidase and exopeptidase activities of cathepsin B. For the most promising inhibitors, the ability to reduce extracellular and intracellular collagen IV degradation was determined, followed by their evaluation in cell-based in vitro models of tumor invasion. The presented data show that we have further defined the structural requirements for cathepsin B inhibition by nitroxoline derivatives and provided additional knowledge that could lead to non-peptidic compounds with usefulness against tumor progression.

METHOD FOR THE PREPARATION OF FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

Bicyclic modulators of androgen receptor function

The invention provides for a pharmaceutical composition capable of modulating the androgen receptor comprising a compound of formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.

BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION

The invention provides compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.

Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

Hetaroyl cyclohexanedione derivatives with herbicidal effect

Hetaroyl derivatives of the formula I where: R1and R2are each hydrogen, nitro, halogen, cyano, thiocyanato, hydroxyl, mercapto, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl or C1-C6-alkoxysulfonyl, where the last 6 radicals may be substituted and/or functionalized; phenyl, phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl, where the last 5 radicals may be substituted; Z is an unsubstituted or substituted four-membered unsaturated, partially or fully saturated chain consisting of three carbons and one nitrogen; Q is unsubstituted or substituted cyclohexane-1,3-dione linked at position 2; and their agriculturally useful salts. A process for preparing the hetaroyl derivatives, compositions comprising them, and the use of these derivatives or these compositions comprising them for controlling undesirable plants.

4-Hetaroylpyrazol derivatives and the use thereof as herbicides

Hetaroyl derivatives of the formula I where: R1and R2are each hydrogen, nitro, halogen, cyano, thiocyanato, hydroxyl, mercapto, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl or C1-C6-alkoxysulfonyl, where the last 6 radicals may be substituted and/or functionalized; phenyl, phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl, where the last 5 radicals may be substituted; Z is an unsubstituted or substituted four-membered unsaturated, partially or fully saturated chain consisting of three carbons and one nitrogen; Q is unsubstituted or substituted hydroxypyrazole linked at position 4; and their agriculturally useful salts. A process for preparing the hetaroyl derivatives, compositions comprising them, and the use of these derivatives or these compositions comprising them for controlling undesirable plants.