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2051-05-0

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Synthesis and anti-influenza virus activity of 7-O-alkylated derivatives related to zanamivir
A series of 7-alkyl ether derivatives related to zanamivir were synthesized using direct alkylation of the C-7 alcohol of sialic acid. Alkyl ether moiety of less than 12 carbons in length showed low nanomolar inhibitory activity against influenza A virus sialidase. Furthermore, their moiety improved influenza A virus plaque reduction activity compared to zanamivir. However, removal of the 8,9-diol of the 7-O-alkyl derivatives resulted in loss of antiviral potency. This result suggests that 8,9-diol must play an important role in binding with both influenza A and B virus sialidases.
Honda, Takeshi,Masuda, Takeshi,Yoshida, Shuku,Arai, Masami,Kaneko, Satoru,Yamashita, Makoto
p. 1925 - 1928
(2007/10/03)

Synthesis and some properties of a homologous series of beta-carboline-3-carboxylic esters
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Previero,Castellano,Scuri,Bianchi,Rizzoli,Galzigna
p. 435 - 441
(2007/10/02)

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Chemical Properties

Boiling Point: 277.6°Cat760mmHg
Flash Point:121.7°C
Density: 1.03g/cm³
Storage Temp.:Refrigerator
Vapor Pressure: 0.00756mmHg at 25°C
Refractive Index: 1.4341
PSA: 54.74000
LogP: 3.84440

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