cas 205110-48-1, Cethromycin | Articles data ｜lookchem

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205110-48-1

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6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY
PROBLEM TO BE SOLVED: To provide 6-O-substituted ketolides with antibacterial activity, having acid stability and enhanced activity toward gram negative bacteria and macrolide resistant gram positive bacteria. SOLUTION: This invention provides 6-O-substituted erythromycin ketolide derivatives such as formula (II) and compositions comprising the compounds. [Y and Z together form a group X; X is ketone, hydroxyimino or the like; or, one of Y and Z is H and the other is hydrogen, hydroxy or the like; Ra is H, hydroxy; Rc is H or a hydroxy protective group; R is a substituted methyl group]. COPYRIGHT: (C)2015,JPOandINPIT
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(2016/10/27)

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Chemical Properties

Melting Point: 211-213°
Boiling Point: 927.1°Cat760mmHg
Flash Point:514.5°C
Density: 1.22g/cm³
Vapor Pressure: 0mmHg at 25°C
PKA: 10.84±0.70(Predicted)
PSA: 162.82000
LogP: 5.43850

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