N6-cycloalkyl- And n6-bicycloalkyl-c5'(c 2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice
To further investigate new potent and selective human A1 adenosine receptor agonists, we have synthesized a series of 5'-chloro-5'-deoxy- and 5'-(2-fluorophenylthio)-5'-deoxy-N6-cycloalkyl(bicycloalkyl)- substituted adenosine and 2'-C-methylade
NUCLEOSIDE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION
Disclosed are compounds, compositions and methods for treating hepatitis C virus infections.
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Page/Page column 113
(2010/02/07)
2'-C-Methyl analogues of selective adenosine receptor agonists: Synthesis and binding studies
2'-C-Methyl analogues of selective adenosine receptor agonists such as (R)-PIA, CPA, CCPA, NECA, and IB-MECA were synthesized in order to further investigate the subdomain that binds the ribose moiety. Binding affinities of these new compounds at A1
Franchetti, Palmarisa,Cappellacci, Loredana,Marchetti, Stefano,Trincavelli, Letizia,Martini, Claudia,Mazzoni, Maria R.,Lucacchini, Antonio,Grifantini, Mario
p. 1708 - 1715
(2007/10/03)
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