20556-16-5

Basic information

• Product Name: H-VAL-ASP-OH
• Synonyms: L-VALYL-L-ASPARTIC ACID;H-VAL-ASP-OH;VAL-ASP
• CAS NO: 20556-16-5
• Molecular Formula: C9H16N2O5
• Molecular Weight: 232.23
• Mol File: 20556-16-5.mol

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• Solubility: Methanol (Slightly), Water (Slightly, Sonicated)
• CAS DataBase Reference: H-VAL-ASP-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-VAL-ASP-OH(20556-16-5)
• EPA Substance Registry System: H-VAL-ASP-OH(20556-16-5)

Safety Data

• Hazardous Substances Data: 20556-16-5(Hazardous Substances Data)

Usage

Uses

Used in Biochemical and Pharmaceutical Research:
H-VAL-ASP-OH is used as a building block for creating peptides and proteins, facilitating the development of novel therapeutic agents and enhancing our understanding of protein structure and function.
Used in Drug Development:
H-VAL-ASP-OH is used as a model compound in drug development, allowing researchers to study its structure and function to design new drugs with specific biological activities.
Used in Drug Delivery Systems:
H-VAL-ASP-OH is used in drug delivery systems to improve the delivery, bioavailability, and therapeutic outcomes of drugs by mimicking the structure of natural peptides and potentially imparting specific biological activities.

Upstream product

• 72-18-4 L-valine 
• 13734-41-3 t-Boc-L-valine 
• 142021-55-4 Boc-Val-Asp-(OH)2 
• 1262519-89-0 Boc-Val-Asp-(OMe)2 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 

Relevant articles and documents

Discovery of Linear Low-Cationic Peptides to Target Methicillin-Resistant Staphylococcus aureus in Vivo

The development and rapid spread of multidrug resistant (MDR) bacteria cause severe public crises. New antibacterial compounds are urgently needed to treat bacterial infections. By circumventing the disadvantages of cationic peptides here, we engineered a short, linear, low-cationic peptide bacaucin-1a, which exhibited remarkable antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). Bacaucin-1a was efficient in the prevention of MRSA associated infections in both in vitro and in vivo models with a unique mode of action. The discovery of low-cationic antibiotic candidates will extend our antibiotic pipeline in the fight against antibiotic resistant bacteria.

Short-peptide-based hydrogel: A template for the in situ synthesis of fluorescent silver nanoclusters by using sunlight

N-terminally Fmoc-protected dipeptide, Fmoc-Val-Asp-OH, forms a transparent, stable hydrogel with a minimum gelation concentration of 0.2 % w/v. The gelation property of the hydrogel was investigated by using methods such as transmission electron microscopy, field-emission scanning electron microscopy, atomic force microscopy and Fourier transform infrared spectroscopy. The silver-ion-encapsulating hydrogel can efficiently and spontaneously produce fluorescent silver nanoclusters under sunlight at physiological pH (7.46) by using a green chemistry approach. Interestingly, in the absence of any conventional reducing agent but in the presence of sunlight, silver ions were reduced by the carboxylate group of a gelator peptide that contains an aspartic acid residue. These clusters were investigated by using UV/Vis spectroscopy, photoluminescence spectroscopy, high-resolution transmission electron microscopy (HR-TEM), atomic force microscopy (AFM) and X-ray diffraction (XRD) studies. Mass spectrometric analysis shows the presence of a few atoms in nanoclusters containing only Ag2. The reported fluorescent Ag nanoclusters show excellent optical properties, including a very narrow emission profile and large Stokes shift (>100 Nm). The reported fluorescent Ag nanoclusters within hydrogel are very stable even after 6 Months storage in the dark at 4 °C. The as-prepared hydrogel-nanocluster conjugate could have applications in antibacterial preparations, bioimaging and other purposes. Silver nanoparticles: An N-terminally protected dipeptide-based hydrogel has been used to make fluorescent silver nanoclusters in the presence of sunlight at room temperature and at physiological pH by using a green chemistry approach. The fluorescent silver nanoclusters exhibit interesting fluorescence properties with a very narrow emission profile and large Stokes shift that may be useful in future applications. Copyright

C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases

This invention is directed to novel (N-substituted) indole ICE/ced-3-inhibitor compounds. The invention is also directed to pharmaceutical compositions of such indole compounds, plus the use of such compositions in the treatment of patients suffering infl