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(R)-3-bromo-N-(4-cyano-3-trifluoromethylphenyl)-2-hydroxy-2-methylpropionamide is a complex chemical compound with the molecular formula C11H11BrF3N2O2. It is characterized by the presence of a bromo group, a cyano group, and a trifluoromethylphenyl group, all attached to a 2-hydroxy-2-methylpropionic acid derivative. (R)-3-broMo-N-(4-cyano-3-trifluoroMethylphenyl)-2-hydroxy-2-MethylpropionaMide is of interest in pharmaceutical research and development due to its potential biological activity and may serve as a key component in the synthesis of other chemical compounds.

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  • (R)-3-bromo-N-(4-cyano-3-trifluoromethylphenyl)-2-hydroxy-2-Methylpropionamide

    Cas No: 206193-17-1

  • USD $ 1.9-2.9 / Gram

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  • 206193-17-1 Structure
  • Basic information

    1. Product Name: (R)-3-broMo-N-(4-cyano-3-trifluoroMethylphenyl)-2-hydroxy-2-MethylpropionaMide
    2. Synonyms: (R)-3-broMo-N-(4-cyano-3-trifluoroMethylphenyl)-2-hydroxy-2-MethylpropionaMide;(2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide;(R)-3-bromo-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide
    3. CAS NO:206193-17-1
    4. Molecular Formula: C12H10BrF3N2O2
    5. Molecular Weight: 351.1192096
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 206193-17-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (R)-3-broMo-N-(4-cyano-3-trifluoroMethylphenyl)-2-hydroxy-2-MethylpropionaMide(CAS DataBase Reference)
    10. NIST Chemistry Reference: (R)-3-broMo-N-(4-cyano-3-trifluoroMethylphenyl)-2-hydroxy-2-MethylpropionaMide(206193-17-1)
    11. EPA Substance Registry System: (R)-3-broMo-N-(4-cyano-3-trifluoroMethylphenyl)-2-hydroxy-2-MethylpropionaMide(206193-17-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 206193-17-1(Hazardous Substances Data)

206193-17-1 Usage

Uses

Given the limited information provided and the need for further research to fully understand its properties and potential applications, the following uses are speculative and based on the compound's structural features:
Used in Pharmaceutical Research and Development:
(R)-3-bromo-N-(4-cyano-3-trifluoromethylphenyl)-2-hydroxy-2-methylpropionamide is likely used as a chemical intermediate for the synthesis of pharmaceutical compounds. Its unique structure, including the bromo and trifluoromethyl groups, may contribute to its potential as a building block for creating novel drugs with specific biological activities.
Used in Chemical Synthesis:
In the chemical industry, (R)-3-bromo-N-(4-cyano-3-trifluoromethylphenyl)-2-hydroxy-2-methylpropionamide could be utilized as a starting material or a reagent in the synthesis of various organic compounds, particularly those with potential applications in the pharmaceutical, agrochemical, or materials science sectors.
Please note that without specific details on the compound's applications, these uses are based on the general properties of similar compounds and the potential for such a molecule to be involved in the pharmaceutical and chemical industries. Further research and development would be necessary to confirm these potential uses.

Check Digit Verification of cas no

The CAS Registry Mumber 206193-17-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,6,1,9 and 3 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 206193-17:
(8*2)+(7*0)+(6*6)+(5*1)+(4*9)+(3*3)+(2*1)+(1*7)=111
111 % 10 = 1
So 206193-17-1 is a valid CAS Registry Number.

206193-17-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

1.2 Other means of identification

Product number -
Other names R-2

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:206193-17-1 SDS

206193-17-1Relevant articles and documents

Exploration and Biological Evaluation of Basic Heteromonocyclic Propanamide Derivatives as SARDs for the Treatment of Enzalutamide-Resistant Prostate Cancer

He, Yali,Hwang, Dong-Jin,Ponnusamy, Suriyan,Thiyagarajan, Thirumagal,Mohler, Michael L.,Narayanan, Ramesh,Miller, Duane D.

, p. 11045 - 11062 (2021/08/03)

A series of propanamide derivatives were designed, synthesized, and pharmacologically characterized as selective androgen receptor degraders (SARDs) and pan-antagonists that exert a broad-scope androgen receptor (AR) antagonism. Incorporating different ba

Meta -Non-flat substituents: A novel molecular design to improve aqueous solubility in small molecule drug discovery

Ichikawa, Yuki,Hiramatsu, Michiaki,Mita, Yusuke,Makishima, Makoto,Matsumoto, Yotaro,Masumoto, Yui,Muranaka, Atsuya,Uchiyama, Masanobu,Hashimoto, Yuichi,Ishikawa, Minoru

supporting information, p. 446 - 456 (2021/01/29)

Aqueous solubility is a key requirement for small-molecule drug candidates. Here, we investigated the regioisomer-physicochemical property relationships of disubstituted benzenes. We found that meta-isomers bearing non-flat substituents tend to possess the lowest melting point and the highest thermodynamic aqueous solubility among the regioisomers. The examination of pharmaceutical compounds containing a disubstituted benzene moiety supported the idea that the introduction of a non-flat substituent at the meta position of a benzene substructure would be a promising approach for medicinal chemists aiming to improve the thermodynamic aqueous solubility of drug candidates, even though it might not be universally effective. This journal is

PYRAZOLYLPROPANAMIDE COMPOUNDS AND USES THEREOF FOR TREATMENT OF PROSTATE CANCER

-

Paragraph 00194; 00192, (2021/10/11)

This invention relates to pyrazolylpropanamide compounds and uses thereof for treatment of prostate cancer, advanced prostate cancer, refractory prostate cancer, AR overexpressing prostate cancer, castration-resistant prostate cancer, castration-sensitive

Pyrazol-1-yl-propanamides as SARD and Pan-Antagonists for the Treatment of Enzalutamide-Resistant Prostate Cancer

He, Yali,Hwang, Dong-Jin,Ponnusamy, Suriyan,Thiyagarajan, Thirumagal,Mohler, Michael L.,Narayanan, Ramesh,Miller, Duane D.

, p. 12642 - 12665 (2020/11/13)

We report herein the design, synthesis, and pharmacological characterization of a library of novel aryl pyrazol-1-yl-propanamides as selective androgen receptor degraders (SARDs) and pan-Antagonists that exert broad-scope AR antagonism. Pharmacological ev

Synthesis method of nicotinate

-

Paragraph 0026-0033; 0047-0055; 0068-0075, (2020/05/01)

The invention belongs to the technical field of compound preparation, and in particular, relates to (S)-1-((4-cyano-3-(trifluoromethyl)phenyl)amino)-3-(4-cyanophenoxy)-2-methyl-1-oxopropan-2-yl nicotinate and a synthesis method thereof. The method compris

ANTI-CANCER NUCLEAR HORMONE RECEPTOR-TARGETING COMPOUNDS

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Page/Page column 145; 146, (2020/11/30)

The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

Synthetic method of alpha-hydroxypropanamide derivatives with optical activity

-

Paragraph 0023; 0024, (2019/06/05)

The invention discloses a synthetic method of alpha-hydroxypropanamide derivatives with optical activity and belongs to the field of organic synthesis. Proline taken as a chiral auxiliary, as well asmethacryloyl chloride, is subjected to acylation, bromination and chiral auxiliary removal, a product and 4-cyano-3-trifluoromethylaniline are subjected to nucleophilic substitution, and 3-bromo-2-hydroxy-2-methyl-N-[(4-cyano-3-trifluoromethyl)phenyl]propanamide is obtained and subjected to nucleophilic substitution with 4-cyanophenol, and the compound 3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethylphenyl]-2-hydroxy-2-methylpropanamide with optical activity is prepared. 3-bromo-2-hydroxy-2-methyl propionic acid and 4-nitro-3-trifluoromethylaniline are subjected to aminolysis, a product is subjected to nucleophilic substitution with paracetamol, and the compound 3-(4-acetoxyphenoxy)-N-[4-nitro-3-(trifluoromethylphenyl]-2-hydroxy-2-methylpropanamide with optical activity is prepared. The efficient synthetic method of the alpha-hydroxypropanamide derivatives with optical activity is provided.

SELECTIVE ANDROGEN RECEPTOR DEGRADER (SARD) LIGANDS AND METHODS OF USE THEREOF

-

Paragraph 00367, (2019/12/04)

This invention is directed to selective androgen receptor degrader (SARD) compounds including heterocyclic rings and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedys disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity

Hwang, Dong-Jin,He, Yali,Ponnusamy, Suriyan,Mohler, Michael L.,Thiyagarajan, Thirumagal,McEwan, Iain J.,Narayanan, Ramesh,Miller, Duane D.

, p. 491 - 511 (2019/01/11)

In our effort to find small-molecule treatments of advanced prostate cancers (PCs), a novel series of indolyl and indolinyl propanamides (series II and III) were discovered as selective androgen receptor degraders (SARDs). Initial studies of androgen receptor (AR) antagonist (1) and agonist (2) propanamides yielded a tertiary aniline (3) with novel SARD activity but poor metabolic stability. Cyclization to II and III produced submicromolar AR antagonism and protein degradation selective to AR and AR splice variant (AR SV). II and III maintained potency against enzalutamide-resistant (Enz-R) mutant ARs and PC cells and were efficacious in Enz-R xenografts, suggesting their potential to treat advanced PCs. Design, synthesis, and biological activity of novel SARDs that could potentially be used for the treatment of a wide spectrum of PCs including castration-resistant, Enz-R, and/or AR SV-dependent advanced PCs that are often untreatable with known hormone therapies are discussed.

ANTI-CANCER NUCLEAR HORMONE RECEPTOR-TARGETING COMPOUNDS

-

Page/Page column 211; 212, (2019/12/04)

The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

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