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4-(2,4-DIFLUOROPHENYL)-3-THIOSEMICARBAZIDE is a thiosemicarbazide derivative with the molecular formula C8H7F2N3S. It features a 2,4-difluorophenyl group attached to a thiosemicarbazide moiety, which endows it with potential applications in medicinal chemistry and drug development. 4-(2,4-DIFLUOROPHENYL)-3-THIOSEMICARBAZIDE is known for its ability to inhibit specific enzymes and biological pathways, and it may also possess antimicrobial and antifungal properties. Further research and testing are necessary to fully explore its potential uses and effects.

206559-58-2

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206559-58-2 Usage

Uses

Used in Medicinal Chemistry:
4-(2,4-DIFLUOROPHENYL)-3-THIOSEMICARBAZIDE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its ability to inhibit certain enzymes and biological pathways makes it a promising candidate for the development of new drugs targeting specific diseases.
Used in Drug Development:
In the pharmaceutical industry, 4-(2,4-DIFLUOROPHENYL)-3-THIOSEMICARBAZIDE is used as a lead compound for the discovery and optimization of novel therapeutic agents. Its unique structure and properties allow researchers to explore its potential in treating a range of medical conditions.
Used in Antimicrobial Applications:
4-(2,4-DIFLUOROPHENYL)-3-THIOSEMICARBAZIDE is used as an antimicrobial agent for its potential to inhibit the growth of bacteria and other microorganisms. Its effectiveness in this application could contribute to the development of new antibiotics and antimicrobial treatments.
Used in Antifungal Applications:
In the field of antifungal research, 4-(2,4-DIFLUOROPHENYL)-3-THIOSEMICARBAZIDE is used as a potential antifungal agent. Its ability to target and inhibit fungal growth could lead to the development of new treatments for fungal infections.

Check Digit Verification of cas no

The CAS Registry Mumber 206559-58-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,6,5,5 and 9 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 206559-58:
(8*2)+(7*0)+(6*6)+(5*5)+(4*5)+(3*9)+(2*5)+(1*8)=142
142 % 10 = 2
So 206559-58-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H7F2N3S/c8-4-1-2-6(5(9)3-4)11-7(13)12-10/h1-3H,10H2,(H2,11,12,13)

206559-58-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2,4-Difluorophenyl)hydrazinecarbothioamide

1.2 Other means of identification

Product number -
Other names 1-amino-3-(2,4-difluorophenyl)thiourea

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:206559-58-2 SDS

206559-58-2Relevant articles and documents

Synthesis and evaluation of new thiadiazole derivatives as potential inhibitors of human carbonic anhydrase isozymes (hCA-I and hCA-II)

Altintop, Mehlika Dilek,Ozdemir, Ahmet,Kucukoglu, Kaan,Turan-Zitouni, Gulhan,Nadaroglu, Hayrunnisa,Kaplancikli, Zafer Asim

, p. 32 - 37 (2015)

2-[[5-(2,4-Difluoro/dichlorophenylamino)-1,3,4-thiadiazol-2-yl]thio] acetophenone derivatives (3a-s) were designed as human carbonic anhydrase isozymes (hCA-I and hCA-II) inhibitors and synthesized. hCA-I and hCA-II were purified from erythrocyte cells by

4-indole-substituted thiourea derivative as well as preparation method and application thereof

-

Paragraph 0051-0058, (2021/04/21)

The invention discloses a 4indole substituted thiosemicarbazide derivative as well as a preparation method and application thereof, and belongs to the technical field of organic synthesis. The structural formula of the 4-indole substituted thiosemicarbazide derivative is shown as a formula (I), wherein in the formula, R is H, halogen, C1-C6 alkyl or C1-C6 alkoxy; the preparation method is low in reaction cost, high in yield, simple and easy to control in reaction process and suitable for industrial production, and the derivative has anti-hepatic fibrosis activity and can be used for preparing anti-hepatic fibrosis drugs and researching the structure-function relationship of the compounds.

Synthesis and Antiproliferative Activity of New Thiosemicarboxamide Derivatives

Chen, Jun,Fang, Meijuan,Guo, Yafei,Hu, Hongyu,Hu, Sangsang,Sun, Ke,Wu, Jun,Xue, Yuhua

, (2021/11/09)

To discover new anticancer agents, two series of thiosemicarboxamide derivatives were synthesized and evaluated for their antiproliferative activity against human cancer cells in vitro. Most target compounds (especially 3f, 3g, and 3h) exhibit potent antiproliferative activity against HeLa cells. Importantly, compound 3h, bearing a 4-methylphenyl substituent at N position of thiourea moiety, has significant and broad-spectrum inhibitory activities against cancer cells (HepG2, HeLa, MDA-MB231, A875, and H460 cells) with low IC50 values (5.0 μM) and shows low toxicity to normal LO2 and MRC-5 cells. Further studies show that compound 3h exerts high inhibitory activity in cancer cells by inducing the G2/M-phase arrest of cancer cells. Collectively, this study presents compound 3h as a new entity for the development of cell cycle arrest inducers for the treatment of cancer.

Synthesis of novel quinoline-thiosemicarbazide hybrids and evaluation of their biological activities, molecular docking, molecular dynamics, pharmacophore model studies, and ADME-Tox properties

Darji, Drashti G.,Patel, Dhaval B.,Patel, Hitesh D.,Patel, Krupa R.,Rajani, Dhanji P.,Rajani, Smita D.

, (2020/02/13)

In the present study, a novel series of N-((substituted)carbamothioyl)-2,4-dimethylquinoline-3-carboxamide (7a-7s) was synthesized by microwave-assisted method. Structure of these derivatives was examined by spectroscopic techniques such as 1H NMR, 13C NMR, FT-IR, and ESI-MS. Further, the novel synthesized compounds were evaluated for their in-vitro biological activities against antibacterial, antifungal, antimalarial, and antituberculosis activity as well as for in-silico study. The antimalarial results demonstrated that compounds 7c and 7q (0.02 μg/mL) have notable potency against Plasmodium falciparum compared with chloroquine (0.02 μg/mL); compounds 7l (0.10 μg/mL), 7e, 7s (0.19 μg/mL), 7b, 7p (0.15 μg/mL), 7a, 7f, and 7f (0.25 μg/mL) also exhibited good activity against P. falciparum compared with quinine (0.26 μg/mL) as standard drug. Docking was performed on PFDHFR-TS, given the effect of compounds against the P. falciparum strain was excellent in comparison with standard drug. Molecular docking suggested that compounds 7b, 7i and 7c, 7e, and 7l closely bind with the active site of protein 3JSU and 4DP3, respectively, and compared with biological activity. We have also carried out molecular dynamics simulation on the best dock compound 7e complex with PDB: 3JSU to check the stability of docked complex and their molecular interaction. The calculated ADME-Tox descriptors for the synthesized compounds validated good pharmacokinetics properties, suggesting that these compounds could be used as hit for the development of the new active agents.

Synthesis and spectroscopic studies of Ru(II) complexes of steroidal thiosemicarbazones by multi step reaction: As anti-bacterial agents

Khan, Salman A.,Asiri, Abdullah M.

, p. 23 - 28 (2017/06/09)

Ru(II) steroidal metal complexes were synthesized by the reaction of dichlorodicarbonyl ruthenium(II) [Ru(CO)2Cl2]n with Steroidal thiosemicarbazones. Coordination via the thionic sulfur and the azomethine nitrogen atom of

Synthesis, spectral studies and antiamoebic activity of new 1-N-substituted thiocarbamoyl-3-phenyl-2-pyrazolines

Abid, Mohammad,Bhat, Abdul Roouf,Athar, Fareeda,Azam, Amir

scheme or table, p. 417 - 425 (2009/04/18)

Thirty new pyrazoline derivatives were synthesized by cyclization of Mannich bases with thiosemicarbazides being substituted by different cyclic and aromatic amines. The structures of the compounds were elucidated by elemental analyses, UV, IR, 1H and 13C NMR and ESI-MS spectral data. The in vitro antiamoebic activity was evaluated against Entamoeba histolytica in comparison with metronidazole used as reference substance. Out of the 30 compounds screened for antiamoebic activity, 10 (5, 6, 15, 18, 25-30) were found to be better inhibitors of E. histolytica since they showed lesser IC50 values than metronidazole. The preliminary results indicated that the presence of 3-chloro or 3-bromo substituent on the phenyl ring at position 3 of the pyrazoline ring enhanced the antiamoebic activity as compared to unsubstituted phenyl ring. The study suggests that the preliminary activity of these compounds may further be explored for the development of new targets for amoebiasis.

Bis-pyrazolines: Synthesis, characterization and antiamoebic activity as inhibitors of growth of Entamoeba histolytica

Bhat, Abdul R.,Athar, Fareeda,Azam, Amir

scheme or table, p. 426 - 431 (2009/04/18)

The cyclization of chalcone with N-4 substituted thiosemicarbazides under basic condition led to the formation of new compounds, thiocarbamoyl bis-pyrazoline derivatives. The structure of the compounds were elucidated by UV, IR, 1H NMR, 13C NMR and ESI-MS spectral data and thermogravimetric analysis, and their purities were confirmed by elemental analyses. The antiamoebic activity of these complexes was evaluated by microdilution method against HM1:IMSS strain of Entamoeba histolytica and the results were compared with the standard drug, metronidazole. Structure-activity relationship shows that the compound with aromatic substituents at the thiocarbamoyl group was more active than those with the cyclic groups. However, it was clear from the IC50 values that the compounds 15 and 20 are more active and both showed a structural resemblance having an electron withdrawing groups attached to the phenyl ring. MTT assay showed that all the compounds are non-toxic to human kidney epithelial cell line.

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