207305-60-0

Basic information

• Product Name: Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, (2S)- (9CI)
• Synonyms: Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, (2S)- (9CI);BOC-(S)-HABA;(2S)-4-[[(tert-Butoxy)carbonyl]amino]-2-hydroxybutanoic acid;Boc-s-HABA Butanoic acid,4-[[(1,1-diMethylethoxy)carbonyl]aMino]-2-hydroxy-, (2S)- (9CI);Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy
• CAS NO: 207305-60-0
• Molecular Formula: C₉H₁₇NO₅
• Molecular Weight: 219.23498
• Product Categories: N-BOC
• Mol File: 207305-60-0.mol

Chemical Properties

• Boiling Point: 422.8±35.0 °C(Predicted)
• Appearance: /
• Density: 1.204±0.06 g/cm3(Predicted)
• PKA: 3.74±0.10(Predicted)
• CAS DataBase Reference: Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, (2S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, (2S)- (9CI)(207305-60-0)
• EPA Substance Registry System: Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, (2S)- (9CI)(207305-60-0)

Safety Data

• Hazardous Substances Data: 207305-60-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, (2S)(9CI) is used as an intermediate in the synthesis of Plazomicin Sulfate (P579505), the acidic salt of Plazomicin (P579500). Plazomicin is a neoglycoside antibiotic with activity against a broad range of Gram-positive and Gram-negative pathogens. Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, (2S)(9CI) plays a crucial role in the development of new antibiotics to combat multidrug-resistant bacteria, such as Klebsiella pneumoniae and Escherichia coli.

Upstream product

• 3938-83-8 (S)-4-amino-2-hydroxybutanoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 371193-49-6 2-benzyloxy-4-tert-butoxycarbonylamino-butyric acid 
• 371193-51-0 [3-benzyloxy-3-(methoxy-methyl-carbamoyl)-propyl]-carbamic acid tert-butyl ester 
• 1154758-70-9 6',2'-diPNZ-3-Boc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin 
• 1154758-62-9 tert-butyl ((2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-4-((tert-butoxycarbonyl)amino)-6-((S)-4-((tert-butoxycarbonyl)amino)-2-hydroxybutanamido)-3-(((2S,3R)-3-((tert-butoxycarbonyl)amino)-6-(((((4-nitrobenzyl)oxy)carbonyl)amino)methyl)-3,4-dihydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-3,5-dihydroxy-5-methyltetrahydro-2H-pyran-4-yl)(methyl)carbamate 
• 1264366-77-9 C₂₇H₃₆BrN₃O₆ 
• 1264366-91-7 (2R,S)-2-(3-bromophenyl)-2-{(2R)-2-[(2-tert-butoxycarbonylamino)ethyl]-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}-N-butylacetamide 
• 1290070-46-0 C₂₀H₂₉NO₇ 
• 1290070-47-1 C₂₁H₃₁NO₇ 
• 1346507-60-5 C₄₆H₇₅N₇O₁₉ 
• 1154758-72-1 3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin 
• 1154758-73-2 6'-PNZ-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin 
• 1154760-35-6 6'-PNZ-2'-(N-Boc-N-methyl-amino-acetyl)-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin 
• 1154758-71-0 6',2'-diPNZ-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin 
• 1154760-48-1 6'-PNZ-2'-(N-phthalimido-3-amino-propyl)-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin 

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