207919-03-7 Usage
Uses
Used in Pharmaceutical Industry:
(4-CHLORO-3-TRIFLUOROMETHYL)PHENYLTHIOUREA is used as a chemical intermediate for the preparation of Benzotriazines, Triazoles, and Oxadiazoles. These heterocyclic compounds are known to affect the MAPK pathway, which plays a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. By modulating the MAPK pathway, these compounds can potentially be used in the development of drugs targeting various diseases, including cancer and inflammatory disorders.
Used in Chemical Synthesis:
In the field of organic chemistry, (4-CHLORO-3-TRIFLUOROMETHYL)PHENYLTHIOUREA serves as a valuable building block for the synthesis of various complex organic molecules. Its unique structure allows for further functionalization and modification, enabling the creation of new compounds with diverse properties and potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
(4-CHLORO-3-TRIFLUOROMETHYL)PHENYLTHIOUREA is also utilized in research and development settings, where it can be employed as a starting material or a reagent in the synthesis of novel compounds. Its unique structural features make it an attractive candidate for exploring new chemical reactions and developing innovative synthetic routes, ultimately contributing to the advancement of scientific knowledge and the discovery of new applications.
Check Digit Verification of cas no
The CAS Registry Mumber 207919-03-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,7,9,1 and 9 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 207919-03:
(8*2)+(7*0)+(6*7)+(5*9)+(4*1)+(3*9)+(2*0)+(1*3)=137
137 % 10 = 7
So 207919-03-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H6ClF3N2S/c9-6-2-1-4(14-7(13)15)3-5(6)8(10,11)12/h1-3H,(H3,13,14,15)
207919-03-7Relevant articles and documents
Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase
Zhu, Junsheng,Han, Le,Diao, Yanyan,Ren, Xiaoli,Xu, Minghao,Xu, Liuxin,Li, Shiliang,Li, Qiang,Dong, Dong,Huang, Jin,Liu, Xiaofeng,Zhao, Zhenjiang,Wang, Rui,Zhu, Lili,Xu, Yufang,Qian, Xuhong,Li, Honglin
, p. 1123 - 1139 (2015/03/04)
Human dihydroorotate dehydrogenase (HsDHODH) is a flavin-dependent mitochondrial enzyme that has been certified as a potential therapeutic target for the treatment of rheumatoid arthritis and other autoimmune diseases. On the basis of lead compound 4, which was previously identified as potential HsDHODH inhibitor, a novel series of thiazole derivatives were designed and synthesized. The X-ray complex structures of the promising analogues 12 and 33 confirmed that these inhibitors bind at the putative ubiquinone binding tunnel and guided us to explore more potent inhibitors, such as compounds 44, 46, and 47 which showed double digit nanomolar activities of 26, 18, and 29 nM, respectively. Moreover, 44 presented considerable anti-inflammation effect in vivo and significantly alleviated foot swelling in a dose-dependent manner, which disclosed that thiazole-scaffold analogues can be developed into the drug candidates for the treatment of rheumatoid arthritis by suppressing the bioactivity of HsDHODH.
3,4-SUBSTITUTED THIAZOLES AS AMPK ACTIVATORS
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Page/Page column 23, (2010/11/25)
The present application provides novel thiazole derivatives that are useful as activators of Adenosine 5'-Monophosphate-Activated Protein Kinase and pharmaceutical compositions containing such compounds.
