The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents
Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives have been prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Analysis of cell viability data and IC50 values indicated that the presence of a trifluorome
Chappel, Lucy,Leong, Chee-Onn,Mai, Chun-Wai,Meikle, Ian T.,Stanforth, Stephen P.,Truong, Thang V.,Wong, Lai Chun
Chiral 1,2- and 1,3-diol-functionalized chromophores as Lego building blocks for coupled structures
Chiral nitroanilines containing 1,2- or 1,3-diol functionalities have been synthesized by nucleophilic aromatic substitution of fluoronitroanilines with 1-aminopropane-2,3-diols and 2-aminopropane-1,3-diol in the melt. X-ray structure analyses confirm ret
Spange, Stefan,Hofmann, Katja,Walfort, Bernhard,Rueffer, Tobias,Lang, Heinrich
p. 8564 - 8567
(2007/10/03)
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