- Biaryl-pyridoquinazolinone derivatives as anti-cancer agents
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This invention provides a compound having the formula: STR1 wherein: (A) n=2-4; (B) R1 and R2 are the same or different and selected from the group consisting of H, (C1 -C3)alkyl, --CH2 CH2 OH, --CH2 CH2 NH2, and --CH2 CH2 N(CH3)2 or R1 and R2 are alkyl moieties which may taken together to form a 4- to 7-membered ring; (C) R3 is selected from H, --CH3, --CH2 CH3, --CH2 CH2 NH2 ; (D) X is located at the 2-, or 3-position and is selected from the group consisting of 2-naphthyl, 1-naphthyl, 1-phenanthrenyl, 2-phenanthrenyl, 3-phenanthrenyl, 4-phenanthrenyl, 9-phenanthrenyl, phenyl, and mono- or polysubstituted phenyl wherein the substituents are selected from the group consisting of --OR4, --NR5 R6, (C1 -C3) alkyl, --CF3, F, Cl, Br, I, --NO2, --CN, --SO3 H, --SO2 NR5 R6, --CO2 H, --CO2 R4, and phenyl; R4 is H or (C1 -C4)alkyl; R5 and R6 are the same or different and are selected from H, or (C1 -C4)alkyl, or R5 and R6 are alkyl groups which may be taken together to form a 4-7 membered ring; (E) W is selected from H, --OR4, --NR5 R6, (C1 -C3)alkyl, --CF3, F, Cl, Br, I, --NO2, --CN, --SO2 NR5 R6, --CO2 R4 ; or a pharmacologically acceptable salt thereof which is useful as an antineoplastic agent.
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