209328-99-4

Basic information

• Product Name: 2-Fluoro-3-Bromo-5-Aminopyridine
• Synonyms: 2-Fluoro-3-Bromo-5-Aminopyridine;5-Bromo-6-fluoropyridin-3-amine
• CAS NO: 209328-99-4
• Molecular Formula: C5H4BrFN2
• Molecular Weight: 191.0010632
• Product Categories: Pyridine
• Mol File: 209328-99-4.mol

Chemical Properties

• Boiling Point: 305℃
• Flash Point: 139℃
• Appearance: /
• Density: 1.813
• Vapor Pressure: 0.000822mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-Fluoro-3-Bromo-5-Aminopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-3-Bromo-5-Aminopyridine(209328-99-4)
• EPA Substance Registry System: 2-Fluoro-3-Bromo-5-Aminopyridine(209328-99-4)

Safety Data

• Hazardous Substances Data: 209328-99-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-3-Bromo-5-Aminopyridine is used as a building block in the synthesis of pharmaceutical compounds for its ability to contribute to the development of new drugs with potentially valuable properties. The presence of fluorine and bromine atoms enhances its reactivity and allows for the creation of molecules with specific therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Fluoro-3-Bromo-5-Aminopyridine is utilized as a key component in the development of agrochemical products, such as pesticides and herbicides. Its unique structure allows for the design of compounds with targeted biological activity against pests and weeds, contributing to more effective and environmentally friendly agricultural solutions.
Used as a Reagent in Organic Synthesis:
2-Fluoro-3-Bromo-5-Aminopyridine is employed as a reagent in organic synthesis for its capacity to participate in various chemical reactions. This enables the production of new molecules with specific functionalities, which can be further utilized in the creation of bioactive compounds and pharmaceutical intermediates, broadening the scope of chemical research and development.

InChI:InChI=1/C5H4BrFN2/c6-4-1-3(8)2-9-5(4)7/h1-2H,8H2

Upstream product

• 5470-17-7 3-bromo-2-chloro-5-nitropyridine 
• 1868-58-2 3-bromo-2-fluoro-5-nitropyridine 

Relevant articles and documents

FE NANOPARTICLES WITH PPM CONTENTS OF PD, CU AND/OR NI, REACTIONS IN WATER CATALYZED BY THEM

The present application discloses a nanoparticle composition prepared from a mixture comprising: a) a transition metal salt; b) an iron salt; and c) a reducing agent; and methods for the use of such compositions, including the reduction of an organic compound comprising a nitro group to form an organic compound comprising an amine group, the Cu-catalyzed cyclization of an azide and an alkyne (click chemistry) and cross coupling reactions, notably Suzuki-Miyaura reactions. The transition metal salts are in particular Pd, Cu and Ni salts, the content of these metals being typically in the ppm range based on the major constituent Fe in the final products.

Safe and Selective Nitro Group Reductions Catalyzed by Sustainable and Recyclable Fe/ppm Pd Nanoparticles in Water at Room Temperature

As a result of a unique synergy between ligand-free Fe/ppm Pd nanoparticles and PEG-containing designer surfactants, a facile and selective reduction of nitro-containing aromatics and heteroaromatics can be effected in water at room temperature in the presence of NaBH4. This new nanotechnology involves low catalyst loadings, is highly chemoselective, and tolerates a wide variety of functional groups. The process, which includes recycling of the entire aqueous medium, offers a general, environmentally responsible, and notably safe approach to highly valued reductions of nitro-containing compounds.

3-Pyridyl enantiomers and their use as analgesics

The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula I: STR1 or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula I above which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.