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209412-23-7

alpha-(2,6-Dichlorophenyl)-6-[(2,4-difluorophenyl)thio]-3-pyridazineacetamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • alpha-(2,6-Dichlorophenyl)-6-[(2,4-difluorophenyl)thio]-3-pyridazineacetamide

    Cas No: 209412-23-7

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  • α-(2,6-Dichlorophenyl)-6-[(2,4-difluorophenyl)thio]-3-pyridazineacetamide

    Cas No: 209412-23-7

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  • 209412-23-7 Structure

  • Basic information

    1. Product Name: alpha-(2,6-Dichlorophenyl)-6-[(2,4-difluorophenyl)thio]-3-pyridazineacetamide
    2. Synonyms: alpha-(2,6-Dichlorophenyl)-6-[(2,4-difluorophenyl)thio]-3-pyridazineacetamide;2-(6-(2,4-difluorophenylthio)pyridazin-3-yl)-2-(2,6-dichlorophenyl)acetamide
    3. CAS NO:209412-23-7
    4. Molecular Formula: C18H11Cl2F2N3OS
    5. Molecular Weight: 426.2672464
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 209412-23-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: alpha-(2,6-Dichlorophenyl)-6-[(2,4-difluorophenyl)thio]-3-pyridazineacetamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: alpha-(2,6-Dichlorophenyl)-6-[(2,4-difluorophenyl)thio]-3-pyridazineacetamide(209412-23-7)
    11. EPA Substance Registry System: alpha-(2,6-Dichlorophenyl)-6-[(2,4-difluorophenyl)thio]-3-pyridazineacetamide(209412-23-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 209412-23-7(Hazardous Substances Data)

209412-23-7 Usage

Type

Synthetic chemical compound

Pharmacological properties

Potential as an antifungal agent and ability to inhibit certain enzymes

Structure

Contains two chlorophenyl groups and a difluorophenylthio group

Study

Investigated for potential biological activities

Applications

Potential use in medicinal chemistry for developing new pharmaceutical drugs

Interest

Subject of further research for potential pharmaceutical development.

Check Digit Verification of cas no

The CAS Registry Mumber 209412-23-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,9,4,1 and 2 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 209412-23:
(8*2)+(7*0)+(6*9)+(5*4)+(4*1)+(3*2)+(2*2)+(1*3)=107
107 % 10 = 7
So 209412-23-7 is a valid CAS Registry Number.

209412-23-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(2,6-dichlorophenyl)-2-(6-((2,4-difluorophenyl)thio)pyridazin-3-yl)acetamide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:209412-23-7 SDS

209412-23-7Downstream Products

209412-23-7Relevant articles and documents

The discovery of VX-745: A novel and selective p38α kinase inhibitor

Duffy, John P.,Harrington, Edmund M.,Salituro, Francesco G.,Cochran, John E.,Green, Jeremy,Gao, Huai,Bemis, Guy W.,Evindar, Ghotas,Galullo, Vincent P.,Ford, Pamella J.,Germann, Ursula A.,Wilson, Keith P.,Bellon, Steven F.,Chen, Guanging,Taslimi, Paul,Jones, Peter,Huang, Cassey,Pazhanisamy,Wang, Yow-Ming,Murcko, Mark A.,Su, Michael S.S.

supporting information; experimental part, p. 758 - 763 (2011/12/03)

The synthesis of novel, selective, orally active 2,5-disubstituted 6H-pyrimido[1,6-b]pyridazin-6-one p38α inhibitors is described. Application of structural information from enzyme-ligand complexes guided the selection of screening compounds, leading to t

Microwave-assisted Ullmann C-S bond formation: Synthesis of the P38α MAPK clinical candidate VX-745

Bagley, Mark C.,Davis, Terence,Dix, Matthew C.,Fusillo, Vincenzo,Pigeaux, Morgane,Rokicki, Michal J.,Kipling, David

experimental part, p. 8336 - 8342 (2010/03/01)

(Chemical Equation Presented) Microwave irradiation promotes the rapid and efficient reaction of a thiophenol and aryl or heteroaryl halide using a copper or palladium catalyst and a range of ligands, depending upon substrate. Of particular utility is the use of copper(I) iodide (5 mol %) and trans-cyclohexane-1,2-diol as ligand under basic conditions and microwave irradiation to give the corresponding sulfide in high yield. This method for C-S bond formation is applied in the four-step synthesis of the clinical candidate VX-745 in 38% overall yield. The inhibitory activity of VX-745 against p38α MAPK is confirmed in Werner syndrome dermal fibroblasts at 1.0 μM concentration by immunoblot assay. 2009 American Chemical Society.

Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells

Bagley, Mark C.,Davis, Terence,Dix, Matthew C.,Rokicki, Michal J.,Kipling, David

, p. 5107 - 5110 (2008/02/13)

The p38 mitogen-activated protein kinase inhibitor VX-745 is prepared rapidly and efficiently in a four-step sequence using a combination of conductive heating and microwave-mediated steps. Its inhibitory activity was confirmed in hTERT immortalized HCA2

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