20942-69-2

Basic information

• Product Name: 5-tert-butyl-2-chlorophenol
• Synonyms: Phenol, 2-chloro-5-(1,1-dimethylethyl)-
• CAS NO: 20942-69-2
• Molecular Formula: C₁₀H₁₃ClO
• Molecular Weight: 184.66262
• Mol File: 20942-69-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-tert-butyl-2-chlorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-tert-butyl-2-chlorophenol(20942-69-2)
• EPA Substance Registry System: 5-tert-butyl-2-chlorophenol(20942-69-2)

Safety Data

• Hazardous Substances Data: 20942-69-2(Hazardous Substances Data)

Upstream product

• 585-34-2 3-tert-butylphenyol 
• 918445-56-4 5-tert-butyl-2-chlorophenylamine 

Relevant articles and documents

The Catalyst-Controlled Regiodivergent Chlorination of Phenols

Different catalysts are demonstrated to overcome or augment a substrate's innate regioselectivity. Nagasawa's bis-thiourea catalyst was found to overcome the innate para-selectivity of electrophilic phenol chlorination, yielding ortho-chlorinated phenols that are not readily obtainable via canonical electrophilic chlorinations. Conversely, a phosphine sulfide derived from 2,2′-Bis(diphenylphosphino)-1,1′-binaphthyl (BINAP) was found to enhance the innate para-preference of phenol chlorination.

HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS

A compound of formula (I): wherein either B is absent and A and Z are the same or different and are each hydrogen, halogen, alkyl, hydroxy, alkoxy,-CN,-C(Rc)2OH,-N(Rd)C(=X)Rc,-C(=X)N(Rc)(Rd),-S(O)m-Rc,-N(Rc)(Rd)S(O)2,-S(O)2N(R c)(Rd),-N(Re)2, aryl optionally substituted with Ra or-O-aryl optionally substituted with Ra; or B is present and is-(CH2)n-,-C(Rb)2-or-O-, or B taken together with A or Z can be-C=C(Rb)-,-C(Rb)=C-,-CH2-CH(R b)-or-CH(Rb)-CH2-; D is-O-or-S(O) m,-; E is a bond or is-(CH2)n-,-N(R d)-,-(CH2)nN(Rd)-or-N(R d)(CH2)n-; F is-C(=X)-; G is-(CH2 )n-,-N(Rd)-,-(CH2)nN(R d)-or-N(Rd)(CH2)n; J is a bond,-O-,-N(RC)C(=X)-,-C(=X)N(Rc)-,-S(O)m,-,-N(Rc)S(O)m-,-S(O)nN(Rc)-,-N(Re)-or-N(Rg)(Rh); K is a bond, alkylene, cycloalkylene, cycloalkenylene, arylene, heterocycloalkylene, heterocycloalkylene or heteroarylene; and L is hydrogen or a terminal group; has therapeutic utility.

Preparation of 4-Bromo- and 4-Chloro-3-t-butylphenol

4-Bromo- and 4-Chloro-3-butylphenol, two potent fungistatics, were prepared in an efficient 3-step synthesis from commercially available materials.Crucial to the synthesis is the use of halo-substituents as positional protective groups.