Diversity-Oriented Approach to Spirorhodanines via a [2+2+2] Cyclotrimerization
Spirocyclic compounds have been increasingly utilized in drug discovery due to their inherent three-dimensional structural complexity. Here, we report a diversity oriented approach to spirorhodanines via a [2+2+2] cyclotrimerization reaction with propargyl halides as co-partners. In another sequence, we employed o-xylylene dibromide as a coupling partner to assemble spirorhodanines.