- TRIAZOLE-PYRIDINYL SUBSTITUTED AZACYCLOHEXYL ACETIC ACID COMPOUNDS AS LPA RECEPTOR ANTAGONISTS
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This application relates to novel substituted azacyclohexyl acetic acid compounds, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with dysregulation of lysophosphatidic acid receptors (LPA).
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Paragraph 0446-0447
(2022/02/28)
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- Studies on Syntheses and Reaction of Methoxypyridazines. I. Methoxylation of 3,4,5-Trichloropyridazine
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The reaction of 3,4,5-trichloropyridazine (1) with 1 eq amount of NaOMe resulted in the formation of three dichloromonomethoxypyridazines (2, 3-OMe; 3, 4-OMe; 4, 5-OMe) in the ratio of 1:3:6.The 4-OMe compound 3 was isolated from the reaction mixture and the 3-OMe compound 2 was syntesizsed independently.Further methoxylation of 2, 3 and 4 was also investigated in order to prepare various substituted pyrazines.Keywords - 3,4,5-trichloropyridazine; methoxylation; dichloromonomethoxypyridazine; monochlorodimethoxypyridazine; pyridazinone; 3,4,5-trimethoxypyridazine
- Nagashima, Hiromu,Oda, Hirohisa,Hida, Jun-Ichi,Kaji, Kenji
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p. 421 - 424
(2007/10/02)
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