- Synthesis of Succinonitrile Derivatives by Homocoupling from Cyanohydrin Derivatives with a Low-Valent Titanium Reagent
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A method is described for synthesizing succinonitrile derivatives bearing alkyl or aryl substituents from cyanohydrin derivatives using low-valent titanium. The active species in this reaction is proposed to be a resonance hybrid of the TiIV nitrile enolate and TiIII alkyl radical.
- Endo, Ryusei,Kishida, Atsushi,Matsunaga, Kazuma,Nagasawa, Kokoro,Takatori, Kazuhiko
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- 6-azabicyclo[3.2.1]octanes via copper-catalyzed enantioselective alkene carboamination
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Bridged bicyclic rings containing nitrogen heterocycles are important motifs in bioactive small organic molecules. An enantioselective copper-catalyzed alkene carboamination reaction that creates bridged heterocycles is reported herein. Two new rings are
- Casavant, Barbara J.,Hosseini, Azade S.,Chemler, Sherry R.
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supporting information
p. 2697 - 2702
(2014/09/29)
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- Dual functionalization of allene: facile construction of heteropolycycles mediated by Bronsted acid
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A facile construction of a heteropolycyclic framework is developed by exploiting the dual functionalization of allene. On treatment of phenethyl alcohol or amine bearing a terminal allene with the Bronsted acid, two consecutive reactions to allene, nucleophilic addition of heteroatom and the Friedel-Crafts reaction, occurred to give 2-oxa-or azabicyclo[2.2.2]octane skeleton. Copyright
- Mori, Keiji,Sueoka, Shosaku,Akiyama, Takahiko
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p. 628 - 629
(2011/04/22)
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- Synthesis of α-aryl nitriles through B(C6F5)3-catalyzed direct cyanation of α-aryl alcohols and thiols
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Various α-aryl nitriles have been prepared in excellent yield from the corresponding α-aryl alcohols employing 3 mol % of B(C6F5)3 (1) as Lewis acid catalyst and (CH3)3SiCN (TMSCN) as cyanide source. Cyano transfer from TMSCN to alcohol proceeds within short reaction time at rt. α-Aryl thiols also produce corresponding nitriles in good to excellent yield at reflux condition.
- Rajagopal, Gurusamy,Kim, Sung Soo
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experimental part
p. 4351 - 4355
(2009/09/30)
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- Condensed heterocyclic compounds, their production and use
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The compound STR1 wherein ring A represents a benzene ring; Ar represents an aromatic group; R 1 and R 2 independently represent hydrogen, acyl or hydrocarbon group or R 1 and R 2 taken together with the adjacent nitrogen atom represent a nitrogen-contain
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- Amine compounds, their production and use
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A compound of the formula: STR1 wherein Ar 1 and Ar 2 independently represent an optionally substituted aromatic group; P and Q independently represent a divalent aliphatic hydrocarbon group having at least 2 carbon atoms and optionally having either oxygen or sulfur in the carbon chain; R 1 and R 3 independently represent --CO--R, --CONH--R (R represents a hydrocarbon group or a heterocyclic group) or a hydrocarbon group; R 2 and R 4 independently represent hydrogen or an alkyl group; R 2 and R 4 independently represent hydrogen or an alkyl group; R 1 and R 2 or R 3 and R 4, taken together with the adjacent nitrogen atom, may form a nitrogen-containing heterocyclic group; and j represents 0 or 1, or a salt thereof, has excellent GnRH-receptor antagonizing activity and is useful as a prophylactic and therapeutic agent for hormone-dependent and other diseases.
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