209799-75-7

Basic information

• Product Name: 4H-Pyrrolo3,2-dpyrimidin-4-one, 2-amino-7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-
• Synonyms: 4H-Pyrrolo3,2-dpyrimidin-4-one, 2-amino-7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-
• CAS NO: 209799-75-7
• Molecular Formula: C11H15 N5 O4
• Molecular Weight: 281.27
• Mol File: 209799-75-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4H-Pyrrolo3,2-dpyrimidin-4-one, 2-amino-7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Pyrrolo3,2-dpyrimidin-4-one, 2-amino-7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-(209799-75-7)
• EPA Substance Registry System: 4H-Pyrrolo3,2-dpyrimidin-4-one, 2-amino-7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-(209799-75-7)

Safety Data

• Hazardous Substances Data: 209799-75-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4H-Pyrrolo3,2-dpyrimidin-4-one, 2-amino-7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydrois used as a potential therapeutic agent for various diseases due to its unique molecular structure and biological activities.
Used in Antiviral Applications:
In the field of antiviral research, this compound may be used as a potential antiviral agent, similar to Immucillin-G, a 9-deazanucleoside analog with antiviral, antibacterial, and antimalarial properties. The specific antiviral activity of 4H-Pyrrolo3,2-dpyrimidin-4-one, 2-amino-7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydrowould depend on its ability to target and inhibit viral replication mechanisms.
Used in Antibacterial Applications:
The compound may also be explored for its potential antibacterial properties, contributing to the development of new antibiotics to combat drug-resistant bacterial infections.
Used in Antimalarial Applications:
Similar to its potential antiviral and antibacterial applications, 4H-Pyrrolo3,2-dpyrimidin-4-one, 2-amino-7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydrocould be investigated for its effectiveness against malaria-causing parasites, providing a new avenue for antimalarial drug development.
Used in Drug Delivery Systems:
In the field of drug delivery, this compound could be utilized as a component in the design of novel drug delivery systems, potentially enhancing the bioavailability, targeting, and overall efficacy of various therapeutic agents.

Relevant articles and documents

Inhibitors of nucleoside metabolism

The present invention provides compounds having the formula: wherein A is CH or N; B is chosen from OH, NH2, NHR, H or halogen; D is chosen from OH, NH2, NHR, H, halogen or SCH3; R is an optionally substituted alkyl, aralkyl or aryl group; and X and Y are independently selected from H, OH or halogen except that when one of X and Y is hydroxy or halogen, the other is hydrogen; and Z is OH or, when X is hydroxy, Z is selected from hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted alkyl, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof; and compounds having the formula: wherein A, X, Y, Z and R are defined for compounds of formula (I) where first shown above; E is chosen from CO2H or a corresponding salt form, CO2R, CN, CONH2, CONHR or CONR2; and G is chosen from NH2, NHCOR, NHCONHR or NHCSNHR; or a tautomer thereof, or a pharmaceutically acceptable salt thereof, or an ester thereof, or a prodrug thereof. The present invention also provides the use of the above compounds as pharmaceuticals, pharmaceutical compositions containing the compounds and processes for preparing the compounds.

Inhibitors of nucleoside metabolism

The present invention provides compounds having the formula: STR1 wherein A is CH or N; B is chosen from OH, NH2, NHR, H or halogen; D is chosen from OH, NH2, NHR, H, halogen or SCH3 ; R is an optionally substituted alkyl, aralkyl or aryl group; and X and Y are independently selected from H, OH or halogen except that when one of X and Y is hydroxy or halogen, the other is hydrogen; and Z is OH or, when X is hydroxy, Z is selected from hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted alkyl, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof. The present invention also provides the use of these compounds as pharmaceuticals, pharmaceutical compositions containing the compounds and processes for preparing the compounds.