- Synthesis and Reactions of Endothiopeptides
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Direct replacement of oxygen by sulphur in a peptide bond results in an endothiopeptide.This replacement can be accomplished by use of Lawesson's reagent 1; however, significant limitations are associated with this method.An improved procedure for the dir
- Guziec, Frank S.,Wasmund, Loide Mayer
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p. 1301 - 1353
(2007/10/02)
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- Studies on Amino Acids and Peptides. Part 6. Methods for Introducing Thioamide Bonds into the Peptide Backbone: Synthesis of the Four Monothio Analogues of Leucine Enkephalin
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A methodology for preparing peptide analogues in which a thioamide bond replaces the normal amide bond is described.Thus, the synthesis of the three leucine enkephalin analogues 4>-, 2>-, and 1>-leucine enke
- Clausen, Kim,Thorsen, Michael,Lawesson, Sven-Olov,Spatola, Arno F.
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p. 785 - 798
(2007/10/02)
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- STUDIES ON AMINO ACIDS AND PEPTIDES-I SYNTHESIS OF N-BENZYLOXYCARBONYLENDOTHIODIPEPTIDE ESTERS
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N-Benzyloxycarbonylendothiodipeptide esters, 3, are synthesized without racemization from the corresponding N-benzyloxycarbonyldipeptide esters, 2, using 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide, 1, as thionation reagent.The benzyloxycarbonyl amino-protecting group (Z) is removed from 3 by using HBr-AcOH.
- Clausen, K.,Thorsen, M.,Lawesson, S.-O.
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p. 3635 - 3639
(2007/10/02)
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