NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS
The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(=NH)NH2, which are useful as inhibitors of factor Xa.
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Page/Page column 75
(2009/10/01)
Structure-based design of novel guanidine/benzamidine mimics: Potent and orally bioavailable factor Xa inhibitors as novel anticoagulants
As part of an ongoing effort to prepare orally active factor Xa inhibitors using structure-based drug design techniques and molecular recognition principles, a systematic study has been performed on the pharmacokinetic profile resulting from replacing the
Lam, Patrick Y. S.,Clark, Charles G.,Li, Renhua,Pinto, Donald J. P.,Orwat, Michael J.,Galemmo, Robert A.,Fevig, John M.,Teleha, Christopher A.,Alexander, Richard S.,Smallwood, Angela M.,Rossi, Karen A.,Wright, Matthew R.,Bai, Stephen A.,He, Kan,Luettgen, Joseph M.,Wong, Pancras C.,Knabb, Robert M.,Wexler, Ruth R.
p. 4405 - 4418
(2007/10/03)
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