210056-91-0Relevant articles and documents
SUBSTITUTED PROPIONYL DERIVATIVES
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, (2008/06/13)
The present invention relates to a compound represented by the following formula (1): [wherein, X1represents a carboxyl group which may be esterified or the like group; Y1represents a single bond, -O- or -N(R1)-; at least one of A1, A2and A3is a group represented by the following formula (2): -R2-a1-R3-a2→{wherein, R2represents a divalent C2-12hydrocarbon group, R3represents a single bond or a divalent C1-12hydrocarbon group, a1and a2individually represent a single bond, -S-, -SO-, -SO2-, -SO2NH-, -O-, -N(R4)-, -CON(R5)-, -C(=O)- or - Si(R6)(R7)- and → means bonding with Q1, Q2or Q3}, the remaining one or two of A1, A2and A3are the same or different and each independently represents a group represented by the following formula (3): -R8-a3-R9-a4→{wherein, R8and R9individually represent a single bond or a divalent C1-12hydrocarbon group, a3and a4individually represent a single bond, -S-, -SO-, -SO2-, -SO2NH-, -O-, - N(R10)-, -CON(R11)-, -C(=O)- or -SI(R12)(R13)- and → means bonding with Q1, Q2or Q3},; at least one of Q1, Q2and Q3represents a cyclic hydrocarbon group or heterocyclic group and the remaining one or two of Q1, Q2and Q3individually represent a hydrogen atom, a carboxyl group which may be esterified, a hydrocarbon group or a heterocyclic group] or salt thereof; and a pharmaceutical comprising the same as an effective ingredient. The compound exhibits strong squalene synthetase inhibitory action and is therefore useful as a pharmaceutical for the treatment·prevention of hypercholesterolemia, hyperlipemia or arteriosclerosis.
