210169-40-7 Usage
Uses
Used in Pharmaceutical Industry:
(S)-(+)-5,5'-Bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole, min. 98% (S)-DTBM-SEGPHOS is used as a catalytic ligand for the enantioselective synthesis of secondary allylic alcohols via enantioselective reductions of α,β-unsaturated ketones. This application is crucial in the development of chiral pharmaceuticals, as it allows for the creation of specific enantiomers with desired biological activities.
Used in Chemical Synthesis:
In the field of chemical synthesis, (S)-(+)-5,5'-Bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole, min. 98% (S)-DTBM-SEGPHOS is used as a catalytic ligand for the stereoselective preparation of cyclohexanone derivatives via rhodium-catalyzed rearrangement of allyl or allenic cyclobutanols. This process is essential for the synthesis of complex organic molecules with specific stereochemistry, which are often required in various chemical and pharmaceutical applications.
Used in Asymmetric Synthesis:
(S)-(+)-5,5'-Bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole, min. 98% (S)-DTBM-SEGPHOS is employed as a catalytic ligand in the Cu-catalyzed asymmetric conjugate reduction of beta-substituted unsaturated phosphonates to produce optically active beta-stereogenic alkylphosphonates. This application is significant in the synthesis of chiral compounds with potential applications in various industries, including pharmaceuticals and agrochemicals.
Used in the Synthesis of Cyclohexenones:
In the field of organic chemistry, (S)-(+)-5,5'-Bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole, min. 98% (S)-DTBM-SEGPHOS is used as a catalytic ligand for the enantioselective synthesis of cyclohexenones via Rh-catalyzed desymmetrization through enantioselective C-C bond activation and ring expansion of allenyl cyclobutanols. This process is vital for the creation of cyclohexenone derivatives with specific stereochemistry, which are important building blocks in the synthesis of various organic compounds.
Used in the Synthesis of P-stereogenic Alkynylphosphine Oxides:
(S)-(+)-5,5'-Bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole, min. 98% (S)-DTBM-SEGPHOS is utilized as a catalytic ligand for the enantioselective synthesis and crystal structure determination of P-stereogenic alkynylphosphine oxides by Rh-catalyzed [2+2+2] cycloaddition. This application is important in the development of novel P-stereogenic compounds with potential applications in various fields, including materials science and pharmaceuticals.
Reaction
Biaryl bisphosphine ligand with narrow dihedral angle. The DTBM SEGPHOS? ligand, as the ruthenium complex, gives superior enantioselectivity and diastereoselectivity through dynamic kinetic resolution in the asymmetric hydrogenation of a-substituted-β-ketoesters useful in the synthesis of carbapenum antibiotics.
With rhodium, preferential enantioselective hydrogenation of more reactive olefin of extended enone structure.
Rhodium catalyzed chemo-, regio, and entantioselective [2 + 2 + 2] cycloaddition of alkynes with isocyanates.
With copper, enantioselective cross Aldol-type reaction of acetonitrile.
With copper, enantioselective vinylsilane alkenylation of aldehydes.
Gold carbene mediated stereoselective cyclopropanation of propargyl esters.
With copper, enantioselective 1,2-reduction of ketones, and 1,4-reduction of a α,β-usaturated esters.
With copper, catalytic enantioselective Mannich-type reaction.
Enantioselective fluorination of b β-keto esters, tert-butoxycarbonyl lactones and lactmes with Sodeoka's Pd-aqua complex and a fluorinating reagent.
Rh-catalyzed intramolecular olefin or carbonyl hydroacylation.
Check Digit Verification of cas no
The CAS Registry Mumber 210169-40-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,0,1,6 and 9 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 210169-40:
(8*2)+(7*1)+(6*0)+(5*1)+(4*6)+(3*9)+(2*4)+(1*0)=87
87 % 10 = 7
So 210169-40-7 is a valid CAS Registry Number.
