21034-22-0

Basic information

• Product Name: 4-BENZOYLDIHYDRO-2(3H)-FURANONE
• Synonyms: 4-BENZOYLDIHYDRO-2(3H)-FURANONE;CHEMBRDG-BB 9071210;4-Benzoyldihydro-3H-furan-2-one;4-benzoyldihydro-2(3H)-furanone(SALTDATA: FREE);4-benzoyldihydrofuran-2(3H)-one
• CAS NO: 21034-22-0
• Molecular Formula: C₁₁H₁₀O₃
• Molecular Weight: 190.1953
• Mol File: 21034-22-0.mol

Chemical Properties

• Melting Point: 62-64
• Boiling Point: 380.4 °C at 760 mmHg
• Flash Point: 173 °C
• Appearance: /
• Density: 1.24 g/cm³
• Vapor Pressure: 5.47E-06mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: 4-BENZOYLDIHYDRO-2(3H)-FURANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BENZOYLDIHYDRO-2(3H)-FURANONE(21034-22-0)
• EPA Substance Registry System: 4-BENZOYLDIHYDRO-2(3H)-FURANONE(21034-22-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 21034-22-0(Hazardous Substances Data)

Usage

Uses

Used in Fragrance Industry:
4-BENZOYLDIHYDRO-2(3H)-FURANONE is used as a flavoring agent for its sweet, fruity, and slightly caramel-like aroma, enhancing the sensory experience of food, beverages, and personal care products.
Used in Perfumery:
In the production of perfumes and colognes, 4-BENZOYLDIHYDRO-2(3H)-FURANONE is utilized as a key ingredient to contribute to the complex and appealing scent profiles of these products.
Used in Cosmetics:
4-BENZOYLDIHYDRO-2(3H)-FURANONE is employed in cosmetics for its ability to add pleasant scents and improve the overall sensory appeal of the products.
Used in Pharmaceutical Synthesis:
4-BENZOYLDIHYDRO-2(3H)-FURANONE is used as an intermediate in the synthesis of various pharmaceuticals, highlighting its importance in the development of new medications.
Used in Research and Development:
4-BENZOYLDIHYDRO-2(3H)-FURANONE is studied for its potential antibacterial and antifungal properties, indicating its value in scientific research for the discovery of new antimicrobial agents.
Used in Organic Compounds Synthesis:
As a versatile chemical, 4-BENZOYLDIHYDRO-2(3H)-FURANONE is also used in the synthesis of other organic compounds, demonstrating its broad applicability in chemical research and industrial processes.

InChI:InChI=1/C11H10O3/c12-10-6-9(7-14-10)11(13)8-4-2-1-3-5-8/h1-5,9H,6-7H2

Upstream product

• 50-00-0 formaldehyd 
• 2051-95-8 succinylbenzene 
• 95891-66-0 (Z)-4-Phenyl-4-trimethylsilanyloxy-but-3-enoic acid ethyl ester 

Downstream Products

• 23239-14-7 5-hydroxymethyl-2,6-diphenyl-4,5-dihydro-2H-pyridazin-3-one 
• 91911-29-4 4-Brom-3-benzoyl-buttersaeure-aethylester 
• 106873-49-8 1-(4-Amino-3-nitrophenyl)-4-benzoylpyrrolidin-2-one 
• 76593-29-8 3-Benzoyl-3-butenoic Acid 
• 76593-35-6 3-Benzoyl-4-methoxybutanoic Acid 
• 106873-53-4 4-Benzoyl-1-(p-methoxyphenyl)-pyrrolidin-2-one 
• 23239-13-6 6-phenyl-5-hydroxymethyl-4,5-dihydro-2H-pyridazin-3-one 
• 99877-46-0 β-benzoyl-γ-bromobutyric acid 
• 33048-55-4 5-Methyl-6-phenyl-3(2H)-pyridazinone 
• 106873-50-1 1-(3,4-Diaminophenyl)-4-benzoylpyrrolidin-2-one 
• 106873-51-2 4-Benzoyl-N-<5(6)-(2-methoxycarbonylamino)-benzimidazolyl>pyrrolidin-2-one 
• 127847-31-8 1-acetyl-3-phenyl-4,5-dihydro-4-pyrazoleacetic acid 
• 127847-35-2 3-phenyl-(1H)-4-pyrazoleacetic acid hydrobromide 
• 127847-38-5 3-phenyl-4,5-dihydro-(1H)-4-pyrazoleacetic acid hydrochloride 

Relevant articles and documents

Ureido-Pyridazinone Derivatives: Insights into the Structural and Conformational Properties for STAT3 Inhibition

Three new ureido-pyridazinone derivatives, which are structurally related to the known STAT3 inhibitor AVS-0288, were designed by taking into account the structure-activity relationships determined for several ureido-oxadiazole derivatives previously studied by our group. Their synthesis was first attempted through suitable 5-aminopyridazinone intermediates (6a and 6b), which molecular structures were confirmed by means of X-ray diffraction data on 6a. Amine functionalization was unsuccessful, therefore, an alternative method was devised. Dual-luciferase and AlphaScreen-based assays were used to test their activity. The obtained data were rationalized on the basis of a modeling study, which focused our attention on the geometrical preferences of the ureido moiety. Computational results seem to indicate that both the 1,2,5-oxadiazole ring and the extended ZZ arrangement are essential and probably act in a synergistic way to confer significant activity against STAT3.

Chemistry of the Synthetic Strigolactone Mimic GR24

This research paper describes a second-generation, enantioselective synthesis of (+)-GR24. This new strategy circumvents the need for ozonolysis, which may not be suitable for reactions performed on scale. This flexible new approach is then used to synthesise a novel bromo-GR24 analogue. Finally, the optimal solvent for making GR24 stock solutions is identified.

THERAPEUTIC AGENT FOR DIABETES

A therapeutic agent for diabetes, which comprises a compound of the formula [I] wherein Xis a group of the formula wherein R4and R5are the same or different and each is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, and R6is a hydrogen atom or an amino-protecting group; R1is an optionally substituted alkyl having 1 to 5 carbon atoms, an optionally substituted alkenyl having 2 to 6 carbon atoms and the like, R2is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, R2' is a hydrogen atom, and R3is an optionally substituted alkyl having 1 to 5 carbon atoms and the like, a prodrug thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof and a solvate thereof. The compound of the present invention shows superior blood sugar decreasing action on the state of hyperglycemia, but does not affect the blood sugar when it is in the normal range or in the hypoglycemic state, which means that it is free of serious side effects such as hypoglycemia. Therefore, the compound of the present invention is useful as a therapeutic drug for diabetes and also useful as a preventive of the chronic complications of diabetes.