210346-16-0

Basic information

• Product Name: (2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoic acid
• Synonyms: (2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoic acid;(2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutyric acid;Boc-(S)-2-(aMinoMethyl)-3-Methylbutanoic acid;(S)-2-(((tert-Butoxycarbonyl)aMino)Methyl)-3-Methylbutanoic acid;(Tert-Butoxy)Carbonyl (S)-2-(Aminomethyl)-3-methylbutanoic acid
• CAS NO: 210346-16-0
• Molecular Formula: C₁₁H₂₁NO₄
• Molecular Weight: 231
• Mol File: 210346-16-0.mol

Chemical Properties

• Melting Point: 70-71 °C
• Boiling Point: 360.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.061±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.48±0.11(Predicted)
• CAS DataBase Reference: (2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoic acid(210346-16-0)
• EPA Substance Registry System: (2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoic acid(210346-16-0)

Safety Data

• Hazardous Substances Data: 210346-16-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(2S)-2-[(tert-Butoxycarbonyl)amino]methyl-3-methylbutanoic acid is used as a key building block for the synthesis of various pharmaceuticals. Its Boc-protected structure allows for the controlled assembly of complex peptide sequences, which are essential components of many drugs, including antibiotics, antivirals, and anticancer agents.
Used in Bioconjugation:
In the field of bioconjugation, (2S)-2-[(tert-Butoxycarbonyl)amino]methyl-3-methylbutanoic acid serves as a versatile linker for attaching biologically active molecules to other entities, such as nanoparticles, antibodies, or other peptides. The Boc protecting group enables selective deprotection and subsequent conjugation, allowing for the precise control of the bioconjugation process.
Used in Organic Chemistry:
(2S)-2-[(tert-Butoxycarbonyl)amino]methyl-3-methylbutanoic acid is also utilized in organic chemistry for the synthesis of various organic compounds. Its Boc-protected amino group can be selectively deprotected and further functionalized, enabling the creation of a wide range of chemical structures with potential applications in materials science, catalysis, and other areas.
Used in Peptide Synthesis:
As a Boc-protected amino acid, (2S)-2-[(tert-Butoxycarbonyl)amino]methyl-3-methylbutanoic acid is extensively used in the synthesis of peptides. The Boc protecting group allows for the stepwise assembly of peptide chains, minimizing side reactions and facilitating the synthesis of complex peptide sequences with high purity and yield. This is particularly important in the development of therapeutic peptides and peptide-based drugs.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 203854-54-0 (2S)-([amino]methyl)-3-methylbutanoic acid 
• 27675-38-3 (E)-3-methyl-1-nitro-but-1-ene 
• 903889-49-6 C₆H₁₅NO 
• 941292-85-9 (S)-tert-butyl 2-(hydroxymethyl)-3-methylbutylcarbamate 

Downstream Products

• 1379661-63-8 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-3-methyl-2-((piperidin-1-yl)methyl)butyl)thiourea 
• 631899-22-4 Boc-(S)-β²-HVal-(S)-β³-HPhe-OBn 
• 200400-98-2 (S)-2-({(S)-3-[(S)-2-(tert-Butoxycarbonylamino-methyl)-3-methyl-butyrylamino]-butyrylamino}-methyl)-4-methyl-pentanoic acid benzyl ester 

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