210355-09-2

Basic information

• Product Name: 4-amino-1-[[(2R)-2-(hydroxymethyl)cyclopropylidene]methyl]pyrimidin-2-one
• CAS NO: 210355-09-2
• Molecular Formula: C₉H₁₁N₃O₂
• Molecular Weight: 193.2025
• Mol File: 210355-09-2.mol

Chemical Properties

• Boiling Point: 386.8°C at 760 mmHg
• Flash Point: 187.7°C
• Density: 1.51g/cm³
• Vapor Pressure: 1.4E-07mmHg at 25°C
• Refractive Index: 1.706
• CAS DataBase Reference: 4-amino-1-[[(2R)-2-(hydroxymethyl)cyclopropylidene]methyl]pyrimidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-1-[[(2R)-2-(hydroxymethyl)cyclopropylidene]methyl]pyrimidin-2-one(210355-09-2)
• EPA Substance Registry System: 4-amino-1-[[(2R)-2-(hydroxymethyl)cyclopropylidene]methyl]pyrimidin-2-one(210355-09-2)

Safety Data

• Hazardous Substances Data: 210355-09-2(Hazardous Substances Data)

Upstream product

• 14631-20-0 4-N-Acetylcytosine 
• 210355-11-6 (E)-N⁴-benzoyl-1-{[(2-hydroxymethyl)cyclopropylidene]methyl}cytosine 

Relevant articles and documents

Phosphoralaninate pronucleotides of pyrimidine methylenecyclopropane analogues of nucleosides: Synthesis and antiviral activity

□ The Z- and E-thymine and cytosine pronucleotides 3d, 4d, 3e, and 4e of methylenecyclopropane nucleosides analogues were synthesized, evaluated for their antiviral activity against human cytomegalovirus (HCMV), herpes simplex virus 1 and 2 (HSV-1 and HSV

2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents

Compounds which are active against viruses have the following Formulas: wherein B is a purine or pyrimidine heterocyclic ring and is preferably selected from the group consisting of 6-aminopurine (adenine), 2,6-diaminopurine, 2-amino-6-azidopurine, 2-amino-6-cyclopropylaminopurine, 6-hydroxypurine (hypoxanthine), 2-amino-6-halo substituted purines, 2-amino-6-alkoxy substituted purines, 2-amino-6-hydroxypurine (guanine), 3-deazapurines, 7-deaza-purines, 8-azapurines, cytosine, 5-halo substituted cytosines, 5-alkyl substituted cytosines, thymine, uracil and 6-azapyrimidines; X is O; and, R1 and R2 are alkyl or aryl groups. The compounds of the present invention also include the R- and S-enantiomers of the above compounds. The R1X and/or R2X can also be amino acid residues with X as NH.