Highly efficient chemoselective construction of 2,2-dimethyl-6-substituted 4-piperidones via multi-component tandem Mannich reaction in ionic liquids
The room temperature ionic liquid [bmim][PF6] has been demonstrated to be an efficient and recyclable medium for highly chemoselective synthesis of 2,2-dimethyl-6-substituted 4-piperidones via a l-proline catalyzed tandem Mannich reaction of ammonia, aldehydes and acetone, and good yields were achieved for aryl and alkyl aldehydes.
Feng, Li-Chun,Sun, Ya-Wei,Tang, Wei-Jun,Xu, Li-Jin,Lam, Kim-Lung,Zhou, Zhongyuan,Chan, Albert S. C.
supporting information; experimental part
p. 949 - 952
(2010/08/20)
Compounds affecting the central nervous system. I. 4-Piperidones and related compounds.
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Ganellin,Spickett
p. 619 - 625
(2007/10/04)
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