Synthesis and evaluation of a series of novel 2-[(4- chlorophenoxy)methyl]benzimidazoles as selective neuropeptide Y Y1 receptor antagonists
A series of novel benzimidazoles (BI) derived from the indole 2 was synthesized and evaluated as selective neuropeptide Y (NPY) Y1 receptor antagonists with the aim of developing antiobesity drugs. In our SAR approach, the (4-chlorophenoxy)methyl group at
Zarrinmayeh, Hamideh,Nunes, Anne M.,Ornstein, Paul L.,Zimmerman, Dennis M.,Arnold, M. Brian,Schober, Douglas A.,Gackenheimer, Susan L.,Bruns, Robert F.,Hipskind, Philip A.,Britton, Thomas C.,Cantrell, Buddy E.,Gehlert, Donald R.
p. 2709 - 2719
(2007/10/03)
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