211105-00-9Relevant articles and documents
Metabolites of (3-[[4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid
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, (2008/06/13)
The present invention relates to metabolites of (3-{[4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid.
Synthesis of terfenadine and derivatives
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, (2008/06/13)
Processes for preparing compounds having the general formula: STR1 wherein R1a is protected carboxy, carboxy, hydroxymethyl, protected hydroxymethyl, or methyl are disclosed. Processes of the invention begin with a starting material of the general formula II STR2 and elaborate the product by reductive amination of an aldehyde of formula IVa STR3 with α,α-diphenyl-4-piperidinemethanol.
An efficient and facile synthesis of racemic and optically active fexofenadine
Fang, Qun K.,Senanayake, Chris H.,Wilkinson, H. Scott,Waid, Stephen A.,Li, Hui
, p. 2701 - 2704 (2007/10/03)
In efficient and practical method for the synthesis of racemic and optically active (96% ee) fexofenadine is described. The key racemic or optically active lactol intermediate 2 is prepared from readily available tolyl derivative 3.