211308-80-4

Basic information

• Product Name: 6-AMino-5-iodo-nicotinic acid Methyl ester
• Synonyms: 6-AMino-5-iodo-nicotinic acid Methyl ester;Methyl 6-aMino-5-iodonicotinate;Methyl 6-amino-5-iodopyridine-3-carboxylate;ethyl 6-amino-5-iodonicotinate;2-Amino-3-iodopyridine-5-carboxylic acid methyl ester
• CAS NO: 211308-80-4
• Molecular Formula: C₇H₇IN₂O₂
• Molecular Weight: 278.04715
• EINECS: -0
• Mol File: 211308-80-4.mol

Chemical Properties

• Boiling Point: 374.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.918±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.38±0.49(Predicted)
• CAS DataBase Reference: 6-AMino-5-iodo-nicotinic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMino-5-iodo-nicotinic acid Methyl ester(211308-80-4)
• EPA Substance Registry System: 6-AMino-5-iodo-nicotinic acid Methyl ester(211308-80-4)

Safety Data

• Hazardous Substances Data: 211308-80-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Amino-5-iodo-nicotinic acid methyl ester is used as a building block for the synthesis of new drugs and therapeutic agents, contributing to the development of innovative treatments for various diseases and conditions.
Used in Biotechnology Industry:
6-Amino-5-iodo-nicotinic acid methyl ester is used as a component in the creation of biotechnological products, such as diagnostic tools and therapeutic agents, due to its unique chemical properties and potential for modification.
Used in Medicinal Chemistry Research:
6-Amino-5-iodo-nicotinic acid methyl ester is used as a research compound to explore its potential applications in medicinal chemistry, including the design and synthesis of novel drug candidates and the study of its interactions with biological targets.
Used in Academic Research:
6-Amino-5-iodo-nicotinic acid methyl ester is used in academic research settings to investigate its chemical properties, reactivity, and potential applications in various fields, such as materials science, synthetic chemistry, and biochemistry.
Used in Industrial Processes:
6-Amino-5-iodo-nicotinic acid methyl ester may be utilized in industrial processes for the production of specialty chemicals, intermediates, or other compounds that require its unique structural features and reactivity.

Upstream product

• 36052-24-1 methyl 6-aminonicotinoate 

Downstream Products

• 774213-97-7 methyl 3-cyclohexyl-2-(trimethylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate 
• 543740-89-2 6-amino-5-iodonicotinic acid 
• 1027731-01-6 methyl 6-amino-5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]nicotinate 
• 1202278-10-1 (R)-6-(2-(sec-butylamino)thiazol-5-yl)-8-phenyl-imidazo[1,2-a]pyridine-2-carboxylic acid 
• 1202276-43-4 (R)-6-(2-(sec-butylamino)thiazol-5-yl)-N-methyl-8-phenylimidazo[1,2-a]pyridine-2-carboxamide 
• 1202278-09-8 (R)-ethyl 6-(2-(sec-butylamino)thiazol-5-yl)-8-phenylimidazo[1,2-a]pyridine-2-carboxylate 
• 1312017-85-8 1-benzenesulfonyl-2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-vinyl]-1H-pyrrolo[2,3-b]pyridin-5-carboxylic acid methyl ester 
• 1312017-84-7 1-benzenesulfonyl-2-[2-cyclopentyl-1-(toluene-4-sulfonyloxy)-vinyl]-1H-pyrrolo[2,3-b]pyridin-5-carboxylic acid methyl ester 
• 1312017-80-3 2-[1-(4-methanesulfonyl-phenyl)-3-methyl-but-1-enyl]-1H-pyrrolo[2,3-b]pyridin-5-carboxylic acid 
• 1312017-79-0 1-benzenesulfonyl-2-[1-(4-methanesulfonyl-phenyl)-3-methyl-but-1-enyl]-1H-pyrrolo[2,3-b]pyridin-5-carboxylic acid methyl ester 
• 1312017-78-9 1-benzenesulfonyl-2-[3-methyl-1-(toluene-4-sulfonyloxy)-but-1-enyl]-1H-pyrrolo[2,3-b]pyridin-5-carboxylic acid methyl ester 
• 1312018-98-6 2-(2-cyclopentyl-1-{3-fluoro-4-[1-methyl-1-(tetrahydro-pyran-2-yloxy)-ethyl]-phenyl}-ethyl)-1H-pyrrolo[2,3-b]pyridin-5-carboxylic acid 
• 1312018-97-5 2-(2-cyclopentyl-1-{3-fluoro-4-[1-methyl-1-(tetrahydro-pyran-2-yloxy)-ethyl]-phenyl}-ethyl)-1H-pyrrolo[2,3-b]pyridin-5-carboxylic acid methyl ester 
• 1312018-96-4 2-(2-cyclopentyl-1-{3-fluoro-4-[1-methyl-1-(tetrahydro-pyran-2-yloxy)-ethyl]-phenyl}-vinyl)-1H-pyrrolo[2,3-b]pyridin-5-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABAA receptor agonists

A series of 6-aminonicotinic acid analogues have been synthesized and pharmacologically characterized at native and selected recombinant GABA A receptors. 6-Aminonicotinic acid (3) as well as 2- and 4-alkylated analogues (9-11, 14-16) display low to mid-micromolar GABAAR binding affinities to native GABAA receptors (Ki 1.1-24 μM). The tetrahydropyridine analogue of 3 (22) shows low-nanomolar affinity (K i 0.044 μM) and equipotency as an agonist to GABA itself as well as the standard GABAA agonist isoguvacine. Cavities surrounding the core of the GABA binding pocket were predicted by molecular interaction field calculations and docking studies in a α1β 2γ2 GABAA receptor homology model, and were confirmed by affinities of substituted analogues of 3. The tight steric requirements observed for the remarkably few GABAAR agonists reported to date is challenged by our findings. New openings for agonist design are proposed which potentially could facilitate the exploration of different pharmacological profiles within the GABAAR area.

AZAINDOLE GLUCOKINASE ACTIVATORS

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SULFOXIMINES AS KINASE INHIBITORS

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INDOLE ACETAMIDES AS INHIBITORS OF THE HEPATITIS C VIRUS NS5B POLYMERASE

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Azaindole derivatives as Factor Xa inhibitors

The present invention relates to compounds of the formula I wherein R0 ; R1 ; R2 ;Q; V, G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.