211616-63-6Relevant articles and documents
A novel, efficient, and recyclable biocatalyst for Michael addition reactions and its iron(iii) complex as promoter for alkyl oxidation reactions
Khalil, Khaled D.,Ibrahim, Enas I.,Al-Sagheer, Fakhreia A.
, p. 1410 - 1416 (2016/03/08)
Chitosan-g-poly(2-cyano-1-(pyridin-3-yl)allyl acrylate) (Cs-g-PCPA), having a grafting percentage (G%) of 64%, was prepared and was then subjected to complexation with iron(iii) (Cs-g-PCPA/Fe(iii)). The results of the catalytic studies demonstrated that Cs-g-PCPA serves as an efficient, recyclable and eco-friendly, basic catalyst for Michael addition reactions, which produce adducts in high yields under mild conditions. Moreover, a Cs-g-PCPA-supported iron(iii) complex was prepared and was then characterized by using FESEM, XRD, TGA, and XPS. In addition, the EDS plot of the Fe(iii) chelate confirms the presence of a relatively high amount (13%) of Fe(iii). The Cs-g-PCPA (G% = 64)-supported iron(iii) complex (Cs-g-PCPA/Fe(iii)) in the presence of H2O2 can be used to oxidize methyl pyridazinyl carbonitriles to form the corresponding fused furan derivatives efficiently. These polymeric catalysts are stable such that they can be recycled and reused more than five times without losing their catalytic activity.
Antimitotic activity on sea urchin embryonic cells of seven antiparasitic morita-baylis-hillman adducts: A potential new class of anticancer drugs
Leite, Jocelmo C. A.,Marques-Santos, Luis F.,Claudio Jr., G. L.,Silva, Fabio P. L.,Sousa, Suervy C. O.,Vasconcellos, Mario L. A. A.
, p. 1003 - 1011,9 (2012/12/12)
In the present work we described improvements in the 1-7 antiparasitic Morita-Baylis-Hillman Adducts synthesis and their antimitotic activity on sea urchin embryonic cells. The 2-[Hydroxy(2-nitrophenyl)methyl]acrylonitrile (1) and 2-[Hydroxy(4-bromophenyl
Highly efficient synthesis of novel Morita-Baylis-Hillman adducts from activated ketones using a DABCO-based hydroxy ionic liquid (HIL) as a recyclable catalyst-solvent
Khalafi-Nezhad, Ali,Mohammadi, Somayeh
experimental part, p. 1725 - 1735 (2012/07/01)
A highly efficient non-imidazolium DABCO-based ionic liquid has been prepared for the synthesis of biologically active Morita-Baylis-Hillman adducts from activated ketones. The results show that the ionic liquid is very efficient in the Morita-Baylis-Hill
Microwave irradiation or low temperature improved synthesis of antiparasitic morita-baylis-hillman adducts
Claudio Jr.,Silva, Fabio P.L.,De Oliveira, Ramon G.,Subrinho, Fernanda L.,De Andrade, Natalia G.,Vasconcellos, Mario L.A.A.
scheme or table, p. 2220 - 2224 (2012/02/03)
It is reported the synthesis of 24 Morita-Baylis-Hillman adducts (3a-3l/6a-6l) using microwave irradiation at 80 °C or conventional protocol at 0 °C to promote the reactions between aromatic aldehydes and methyl acrylate or acrylonitrile (81-99%). It is shown that the reaction of 2-hydroxy(4-bromophenyl)methyl acrylate formation is reversible at 120 °C.
Efficient synthesis of 16 aromatic Morita-Baylis-Hillman adducts: Biological evaluation on Leishmania amazonensis and Leishmania chagasi
Junior, Claudio G.L.,De Assis, Priscila A.C.,Silva, Fabio P.L.,Sousa, Suervy C.O.,De Andrade, Natalia G.,Barbosa, Ticiano P.,Neris, Patricia L.N.,Segundo, Luiz V.G.,Anjos, Italo C.,Carvalho, Gabriel A.U.,Rocha, Gerd B.,Oliveira, Marcia R.,Vasconcellos, Mario L.A.A.
experimental part, p. 279 - 284 (2011/02/22)
Sixteen aromatic Morita-Baylis-Hillman adducts (MBHA) 1-16 were efficiently synthesized in a one step Morita-Baylis-Hillman reaction (MBHR) involving commercial aldehydes with methyl acrylate or acrylonitrile (81-100% yields) without the formation of side
Baylis-Hillman reaction under solvent-free conditions - Remarkable rate acceleration and yield enhancement
Saikia, Monmi,Sarma, Jadab C.
experimental part, p. 1271 - 1276 (2011/02/24)
A simple and efficient method has been developed for remarkable rate acceleration and yield enhancement of the Baylis-Hillman reaction under solvent-free "neat conditions" and solvent-less isolation of products. Reaction of equimolar quantities of aldehyd
Improved synthesis of seven aromatic Baylis-Hillman adducts (BHA): Evaluation against Artemia salina Leach. and Leishmania chagasi
Barbosa, Ticiano P.,Junior, Claudio G.L.,Silva, Fabio P.L.,Lopes, Horacimone M.,Figueiredo, Lucas R.F.,Sousa, Suervy C.O.,Batista, Guilherme N.,da Silva, Thiago G.,Silva, Tania M.S.,de Oliveira, Marcia R.,Vasconcellos, Mario L.A.A.
experimental part, p. 1726 - 1730 (2009/05/27)
We described a very efficient procedure to prepare seven aromatic compounds (1-7), a new class of antileishmanial substances, through Baylis-Hillman reaction (BHR). With one, all the Baylis-Hillman adducts were prepared in quantitative yields by reaction
An efficient synthesis of Baylis-Hillman adducts of acrylamide: Pd-catalyzed hydration of Baylis-Hillman adducts of acrylonitrile
Kim, Eun Sun,Lee, Hyun Seung,Kim, Jae Nyoung
body text, p. 6286 - 6289 (2010/01/18)
An efficient palladium-catalyzed two-step protocol for the synthesis of Baylis-Hillman adducts of acrylamide was developed. The method involved the preparation of Baylis-Hillman adducts of acrylonitrile and a Pd-catalyzed hydration of nitrile with acetald
Hydroxyl ionic liquid (HIL)-immobilized quinuclidine for Baylis-Hillman catalysis: Synergistic effect of ionic liquids as organocatalyst supports
Mi, Xueling,Luo, Sanzhong,Xu, Hui,Zhang, Long,Cheng, Jin-Pei
, p. 2537 - 2544 (2007/10/03)
Hydroxyl ionic liquid (HIL) has been explored as a novel support for Baylis-Hillman catalyst. The HIL-supported catalyst showed a better catalytic activity compared to other IL-immobilized catalyst that has no hydroxyl group attached to the IL scaffold. T
Hexamethylenetetramine as a cheap and convenient alternative catalyst in the Baylis-Hillman reaction: Synthesis of aromatic compounds with anti-malarial activity
De Souza,Meireles, Bruno A.,Aguiar, Lucia C. S.,Vasconcellos
, p. 1595 - 1600 (2007/10/03)
Hexamethylenetetramine (7, HMT) is a cheap alternative catalyst in the Baylis-Hillman reaction between aromatic aldehydes and methyl acrylate or acrylonitrile. The use of 0.1 equiv or 1.0 equiv of HMT proved to be an efficient catalyst for the preparation
