- Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol
-
A catalytic amidation method has been developed, employing 2,2,2-trifluoroethanol to facilitate condensation of unactivated esters and amines, enabling the synthesis of a range of amide products in good to excellent yields. Mechanistic studies indicate the reaction proceeds through a trifluoroethanol-derived active ester intermediate.
- Caldwell, Nicola,Jamieson, Craig,Simpson, Iain,Watson, Allan J. B.
-
supporting information
p. 9495 - 9498
(2015/06/08)
-
- Benzofurazan compounds which enhance AMPA receptor activity
-
Compounds of general structural formula (I) are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of behaviors dependent upon AMPA receptors, and in treating conditions, s
- -
-
-
- Benzofurazan compounds for enhancing glutamatergic synaptic responses
-
Compounds of the general structural formula are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of behaviors dependent upon AMPA receptors, and in treating conditions, such as memory impairment, in which AMPA receptors, or synapses utilizing these receptors, are reduced in numbers or efficiency. They may also be used to enhance excitatory synaptic activity in order to restore an imbalance between brain subregions, as in treatment of schizophrenia or schizophreniform behavior.
- -
-
-