- Organogold(III) Metallacyclic Chemistry. Part 31. Self-assembly of the nonametallic gold(III)-silver(I)-sulfido aggregates [{LAu(μ-S)2AuL}3Ag3X2]+ (L=cycloaurated N,N-dimethylbenzylamine li
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Reaction of the gold(III) dihalide complexes [{C6H3(CH2NMe2)-2-R-5}AuX2] (R=OMe, H; X=Cl, Br) with N,N′-dimethylthiourea and silver(I) oxide in refluxing dichloromethane gave the novel gold(III) aggre
- Dinger, Maarten B.,Henderson, William,Nicholson, Brian K.,Robinson, Ward T.
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- Synthesis and crystal structure of the first complex containing a chelating selenourea dianion ligand
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Reaction of N,N′-diphenylselenourea, PhNHC(Se)NHPh, with cis-[PtCl2(PPh3)2] and triethylamine in hot methanol gives the first example of a selenourea dianion complex, [Pt{SeC(=NPh)NPh}(PPh3)2] isolated as a yellow solid in high yield. The structure of the complex was determined by X-ray crystallography and found to be similar to the related thiourea dianion complex [Pt{SC(=NPh)NPh}(PPh3)2], with a Pt-Se-C-N four-membered ring. The antitumour activity (P388 murine leukaemia cells) of the selenourea dianion complex was determined, together with a small selection of related platinum(II)-thiourea dianion complexes (prepared by an analogous method) for comparison. The complex [Pt{SC(=NMe)NMe}(PPh3)2] showed high activity [IC50 1.0 μM], with the other complexes showing moderate to low activity.
- Henderson, William,Nicholson, Brian K.,Dinger, Maarten B.
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p. 428 - 431
(2008/10/09)
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