Novel electrophilic ipso acylation - Detosylation reaction of pyrroles
A pyrrole and two pyrroloindoles that are substituted with a p-toluenesulfonyl group undergo an ipso acylation - detosylation reaction with acid chlorides and aluminum chloride to afford the corresponding acyl-substituted pyrroles and pyrroloindoles.
Pelkey, Erin T.,Gribble, Gordon W.
p. 1338 - 1342
(2007/10/03)
Reaction of 2-Nitroenamines and 2-Nitroalkenyl Sulfides with Ethyl Isocyanoacetate. A Novel Synthesis of 1-Hydroxypyrazoles
We have show that 1-hydroxypyrazoles can be prepared easily and regioselectively from the reaction of nitroenamines with ethyl isocyanoacetate. α,β-Unsaturated aci-nitronates are formed in the reaction and are then hydrolysed to give the products by quenching with acid.