212517-01-6

Basic information

• Product Name: 2-[(4H-1,2,4-TRIAZOL-4-YLAMINO)CARBONYL]BENZENECARBOXYLIC ACID
• Synonyms: 2-[(4H-1,2,4-TRIAZOL-4-YLAMINO)CARBONYL]BENZENECARBOXYLIC ACID;AKOS BC-1890;2-[(4H-1,2,4-triazol-4-yl)carbamoyl]benzoic acid
• CAS NO: 212517-01-6
• Molecular Formula: C10H8N4O3
• Molecular Weight: 232.2
• Mol File: 212517-01-6.mol

Chemical Properties

• Melting Point: 110-112 °C(Solv: ethanol (64-17-5))
• Appearance: /
• Density: 1.51±0.1 g/cm3(Predicted)
• PKA: 3.58±0.36(Predicted)
• CAS DataBase Reference: 2-[(4H-1,2,4-TRIAZOL-4-YLAMINO)CARBONYL]BENZENECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4H-1,2,4-TRIAZOL-4-YLAMINO)CARBONYL]BENZENECARBOXYLIC ACID(212517-01-6)
• EPA Substance Registry System: 2-[(4H-1,2,4-TRIAZOL-4-YLAMINO)CARBONYL]BENZENECARBOXYLIC ACID(212517-01-6)

Safety Data

• Hazardous Substances Data: 212517-01-6(Hazardous Substances Data)

Upstream product

• 584-13-4 4-amino-1,2,4-triazole 
• 85-44-9 phthalic anhydride 

Relevant articles and documents

Complete and Versatile Post-Synthetic Modification on Iron-Triazole Spin Crossover Complexes: A Relevant Material Elaboration Method

In this paper we study the post-synthetic modification (PSM) reaction on solid spin crossover (SCO) [Fe(NH2trz)3]X2 (X=NO3, OTs, Cl, SO4, BF4) complexes with different substrates. The wide access to a diversity of functionalized complexes with imine, amide and carbamide groups from the same amino parent compound demonstrates the synthetic approach value of this method. The as-obtained post-synthetic complexes were studied by IR, solid NMR, elemental analyses, and powder X-ray diffraction, and compared to the corresponding compounds obtained by direct synthesis (DS) routes. Moreover, after digestion of the complexes obtained by PSM reactions, the free ligands were characterized by NMR in solution, which allowed us to indirectly confirm the formation of complexes we wished to synthesize. The study reveals in numerous cases that a complete post-synthetic modification is possible despite the structural cohesion that is established between the 1D coordination chains within these materials. Spin crossover properties of some complexes obtained by both methods are also reported and compared.

Microwave assisted synthesis of N-Arylphthalamic acids with hyperlipidemic activity

A series of substituted N-arylphthalamic acids 3a-i has been synthesized by the reaction of phthalic anhydride 1 and aryl- or heterocyclic amines 2a-i, in the absence of solvents, in a domestic microwave oven. The formation of nine N-arylphthalamic acids was accomplished in 1-3 min giving excellent yields for compounds 3a-g, but moderate yield of compounds 3h and 3i, respectively. Compounds 3h and 3i are new. Interestingly, N-arylphthalamic acids 3a-i induced hyperlipidemia in Swiss white mice and also increased animals' body weight.