Biosynthesis of Estrogens bz Microsomal Placental Aromatase; Isolation and Metabolism of 10β-Hydroxyestr-4-ene-3,17-dione
Incubation of -19-oxoandrost-4-ene-3,17-dione (2a) with microsomal aromatase gave inter alia -10β-hydroxyestr-4-ene-3,17-dione (1), whose analogue (1b) on incubation with the aromatase gave 10β,17β-dihydroxyestr-4-en-3-one (1d) (ca. 10percent) and no estrogens which would indicate that (1b) is not an obligatory estrogen precursor.
Caspi, Eliahu,Dharmaratne, H. Ranjith W.,Shackleton, Cedric