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CAS

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2137047-43-7

VU6005649 is a novel mGlu7/8 receptor agonist that demonstrates excellent central nervous system (CNS) penetration with high Kp values ranging from 1.9 to 5.8 and Kp,uu values between 0.4 and 1.4. This characteristic makes it a promising candidate for various applications in the pharmaceutical and medical fields.

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  • 2137047-43-7 Structure

  • Basic information

    1. Product Name: VU6005649
    2. Synonyms: VU6005649
    3. CAS NO:2137047-43-7
    4. Molecular Formula: C16H12F5N3O
    5. Molecular Weight: 357.277996
    6. EINECS: -0
    7. Product Categories: N/A
    8. Mol File: 2137047-43-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.43±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: -1.73±0.30(Predicted)
    10. CAS DataBase Reference: VU6005649(CAS DataBase Reference)
    11. NIST Chemistry Reference: VU6005649(2137047-43-7)
    12. EPA Substance Registry System: VU6005649(2137047-43-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2137047-43-7(Hazardous Substances Data)

2137047-43-7 Usage

Uses

Used in Pharmaceutical Industry:
VU6005649 is used as a therapeutic agent for targeting mGlu7/8 receptors, which are involved in various neurological and psychiatric disorders. Its ability to penetrate the CNS effectively makes it a potential treatment option for conditions such as anxiety, depression, and chronic pain.
Used in Research and Development:
In the field of research and development, VU6005649 serves as a valuable tool for studying the role of mGlu7/8 receptors in the central nervous system. It can be used to investigate the underlying mechanisms of various neurological and psychiatric disorders, as well as to identify potential drug targets for the development of novel therapeutics.
Used in Drug Delivery Systems:
To enhance the efficacy and bioavailability of VU6005649, researchers may develop innovative drug delivery systems, such as nanoparticles or liposomes, to improve its delivery to the target site within the CNS. This could lead to more effective treatments with reduced side effects and improved patient outcomes.

Check Digit Verification of cas no

The CAS Registry Mumber 2137047-43-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,1,3,7,0,4 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2137047-43:
(9*2)+(8*1)+(7*3)+(6*7)+(5*0)+(4*4)+(3*7)+(2*4)+(1*3)=137
137 % 10 = 7
So 2137047-43-7 is a valid CAS Registry Number.

2137047-43-7Downstream Products

2137047-43-7Relevant articles and documents

Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines

Abe, Masahito,Seto, Mabel,Gogliotti, Rocco G.,Loch, Matthew T.,Bollinger, Katrina A.,Chang, Sichen,Engelberg, Eileen M.,Luscombe, Vincent B.,Harp, Joel M.,Bubser, Michael,Engers, Darren W.,Jones, Carrie K.,Rodriguez, Alice L.,Blobaum, Anna L.,Conn, P. Jeffrey,Niswender, Colleen M.,Lindsley, Craig W.

, p. 1110 - 1115 (2017)

Herein, we report the structure-activity relationships within a series of mGlu7 PAMs based on a pyrazolo[1,5-a]pyrimidine core with excellent CNS penetration (Kps > 1 and Kp,uus > 1). Analogues in this series proved to dis

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