21419-48-7

Basic information

• Product Name: 6-BROMO-QUINAZOLIN-4-YLAMINE
• Synonyms: 6-bromo-4-quinazolinamine;CHEMBRDG-BB 4022407;6-BROMOQUINAZOLIN-4-AMINE;6-BROMO-QUINAZOLIN-4-YLAMINE;4-quinazolinamine, 6-bromo-;6-bromoquinazolin-4-amine(SALTDATA: FREE);4-AMino-6-broMoquinazoline
• CAS NO: 21419-48-7
• Molecular Formula: C₈H₆BrN₃
• Molecular Weight: 224.06
• Mol File: 21419-48-7.mol

Chemical Properties

• Melting Point: >350 °C
• Boiling Point: 385.4 °C at 760 mmHg
• Flash Point: 186.9 °C
• Appearance: /
• Density: 1.744 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 7.04±0.50(Predicted)
• CAS DataBase Reference: 6-BROMO-QUINAZOLIN-4-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-QUINAZOLIN-4-YLAMINE(21419-48-7)
• EPA Substance Registry System: 6-BROMO-QUINAZOLIN-4-YLAMINE(21419-48-7)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 21419-48-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Bromo-quinazolin-4-ylamine is used as a key intermediate in the synthesis of potential drug candidates, particularly for the development of novel therapeutic agents. Its chemical properties and structure make it a valuable component in the creation of new medicines.
Used in Cancer Research:
6-Bromo-quinazolin-4-ylamine is used as an anti-cancer agent, contributing to the development of treatments for various types of cancer. Its inherent properties have been found to exhibit inhibitory effects on cancer cell growth and progression, making it a promising compound for further research and potential clinical applications.
Used in Inflammation Studies:
6-Bromo-quinazolin-4-ylamine is used as an anti-inflammatory agent, aiding in the investigation of inflammatory processes and the development of treatments for inflammatory diseases. Its ability to modulate inflammatory responses is of interest to researchers seeking to understand and treat conditions such as arthritis, asthma, and other inflammatory disorders.
Used in Medicinal Chemistry Research:
6-Bromo-quinazolin-4-ylamine is used as a building block for the synthesis of biologically active molecules, facilitating the discovery and design of new compounds with potential therapeutic applications. Its role in medicinal chemistry research is crucial for advancing the understanding of drug action and the development of more effective treatments.
Used in Biological Research:
6-Bromo-quinazolin-4-ylamine is used as a research tool in the study of various biochemical pathways and disease processes. Its application in biological research helps to uncover the mechanisms underlying different diseases and conditions, potentially leading to the identification of new therapeutic targets and strategies.

Upstream product

• 4692-98-2 5-bromoisatoic anhydride 
• 39263-32-6 2-amino-5-bromobenzonitrile 
• 77287-34-4 formamide 
• 304858-65-9 2-amino-4-bromobenzonitrile 
• 122-51-0 orthoformic acid triethyl ester 
• 38267-96-8 6-bromo-4-chloroquinozoline 

Downstream Products

• 1003025-54-4 6-(4-fluorophenyl)quinazolin-4-amine 

Relevant articles and documents

An organometallic inhibitor for the human repair enzyme 7,8-dihydro-8-oxoguanosine triphosphatase

The probe-based discovery of the first small-molecule inhibitor of the repair enzyme 8-oxo-dGTPase (MTH1) is presented, which is an unconventional cyclometalated ruthenium half-sandwich complex. The organometallic inhibitor with low-nanomolar activity displays astonishing specificity, as verified in tests with an extended panel of protein kinases and other ATP binding proteins. The binding of the organometallic inhibitor to MTH1 is investigated by protein crystallography. Not a canonical inhibitor: A ruthenium complex has been shown to be a low-nanomolar and selective inhibitor of an enzyme that hydrolyzes oxidized purine nucleoside triphosphates. This work provides a blueprint for the discovery and development of organometallic inhibitors of other purine nucleotide binding proteins which rely on ruthenium-coordinated adenine and quinazoline derivatives with tailored coordination spheres. Copyright

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The invention relates to 4-aminoquinazoline grafted acrylamide compounds, a preparation method and application thereof. The compounds have a structure shown as general formula (I) in the specification. According to the invention, a quinazoline compound is adopted as the basis, and acrylamido is introduced into the system to synthesize a series of acrylamido-containing substituted 4-aminoquinazoline compounds, and the compounds have a good inhibiting effect on plant pathogenic bacteria, and have good inhibiting effect on pathogenic bacteria directed at Xanthomonas oryzae pv. Oryzae, Xanthomonasaxonopodis pv. Citri, etc.

Microwave-assisted thermal decomposition of formamide: A tool for coupling a pyrimidine ring with an aromatic partner

Rapid and efficient generation of CO and NH3 in the reaction mixture via microwave-assisted thermal decomposition of formamide may represent a significant improvement over existing methods for coupling a pyrimidine ring with an aromatic partner. This work aims at alerting readers on the probability to observe interesting phenomena and reactions when this very powerful heating mode is associated with thermally unstable reagents.

NOVEL CHEMICAL COMPOUNDS

This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 proteins.