21428-23-9

Basic information

• Product Name: 5-BROMO-6-CHLORO-URACIL
• Synonyms: 5-BROMO-6-CHLORO-URACIL;5-BroMo-6-chloropyriMidine-2,4(1H,3H)-dione
• CAS NO: 21428-23-9
• Molecular Formula: C₄H₂BrClN₂O₂
• Molecular Weight: 225.42788
• Mol File: 21428-23-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-BROMO-6-CHLORO-URACIL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-6-CHLORO-URACIL(21428-23-9)
• EPA Substance Registry System: 5-BROMO-6-CHLORO-URACIL(21428-23-9)

Safety Data

• Hazardous Substances Data: 21428-23-9(Hazardous Substances Data)

Upstream product

• 4270-27-3 6-chlorouracil 

Downstream Products

• 172947-65-8 6-<(2-Amino-4,5-dimethylphenyl)thio>-5-bromouracil 
• 917396-15-7 1,3-Dibenzyl-5-bromo-6-chloropyrimidine-2,4(1H,3H)-dione 
• 79108-65-9 5-Bromo-6-(2-methylamino-phenylsulfanyl)-1H-pyrimidine-2,4-dione 
• 79108-67-1 6-(2-Amino-phenylsulfanyl)-5-bromo-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Triazolopyrimidine heterocycles as cannabinoid receptor modulators

The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds a

Triazolopyrimidine cannabinoid receptor 1 antagonists

The present application describes compounds according to both Formulas I and II, pharmaceutical compositions comprising at least one compound according to either Formula I or II and optionally one or more additional therapeutic agents, and methods of treatment using the compounds according to Formulas I and II both alone and in combination with one or more additional therapeutic agents. The compounds have the following general formulas: including all prodrugs, solvates, pharmaceutically acceptable salts and stereoisomers, wherein R1, R2, R3, R4 and R5 are described herein.

Synthesis and enzymatic evaluation of pyridinium-substituted uracil derivatives as novel inhibitors of thymidine phosphorylase.

A series of water soluble N(1)- and C(6)-substituted uracil pyridinium compounds were prepared as potential inhibitors of thymidine phosphorylase (TP). The C(6)-uracil substituted derivatives were the most active. 1-[(5-Chloro-2,4-dihydroxypyrimidin-6-yl)methyl]pyridinium chloride, was identified as the best inhibitor being 5-fold more potent than the known inhibitor, 6-amino-5-bromouracil.