214402-34-3

Basic information

• Product Name: Pentanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, (4R)- (9CI)
• Synonyms: Pentanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, (4R)- (9CI);(R)-4-(Boc-aMino)-pentanoic acid
• CAS NO: 214402-34-3
• Molecular Formula: C₁₀H₁₉NO₄
• Molecular Weight: 217.26216
• Product Categories: N-BOC
• Mol File: 214402-34-3.mol

Chemical Properties

• Boiling Point: 363.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.081±0.06 g/cm3(Predicted)
• PKA: 4?+-.0.10(Predicted)
• CAS DataBase Reference: Pentanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, (4R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, (4R)- (9CI)(214402-34-3)
• EPA Substance Registry System: Pentanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, (4R)- (9CI)(214402-34-3)

Safety Data

• Hazardous Substances Data: 214402-34-3(Hazardous Substances Data)

Upstream product

• 402955-77-5 (R)-2-methyl-5-oxopyrrolidine-1-carboxylic acid tert-butyl ester 
• 911050-47-0 tert-butyl [(1R)-2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-1-methylethyl]carbamate 
• 911050-46-9 tert-butyl [(1R)-2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-1-methyl-2-oxoethyl]carbamate 
• 3744-87-4 Boc-(R)-Ala 
• 10312-37-5 methyl 4-nitropentanoate 
• 930596-36-4 (±)-methyl 4-(tert-butoxycarbonyl)amino-pentanoate 

Downstream Products

• 911050-48-1 methyl (4R)-4-[(4-phenoxybenzoyl)amino]pentanoate 
• 911050-49-2 methyl (2S,4R)-2-methyl-4-[(4-phenoxybenzoyl)amino]pentanoate 
• 911050-50-5 (2S,4R)-2-methyl-4-[(4-phenoxybenzoyl)amino]pentanoic acid 

Relevant articles and documents

Effect of the Substituent and Amino Group Position on the Lipase-Catalyzed Resolution of γ-Amino Esters: A Molecular Docking Study Shedding Light on Candida antarctica lipase B Enantioselectivity

The kinetic resolution of N-tert-butoxycarbonyl γ-amino methyl esters bearing different stereocenters at alpha (γ2), beta (γ3), or gamma (γ4) positions was carried out by enantioselective hydrolysis with Candida antarctica lipase B (CaLB) in 2-methyl-2-butanol solvent. The results show that the process is significantly less enantioselective for the γ2-amino methyl ester (E=2.5), the γ3-amino methyl ester (E=7.6), and the γ4-amino methyl ester (E=8.3) when compared with the kinetic resolution of analogous N-protected β3-amino esters (E>80). Based on these results, molecular docking studies were carried out, through which particular regions in the CaLB catalytic cavity were analyzed. The steric exclusion region composed of Ile189 and Val190 residues, together with the amino bonding region that induces a hydrogen bond with the Asp134 residue, appear to be responsible for the high selectivity in the resolution of carboxylic acid derivatives with beta stereocenters. This interaction is well preserved for β-amino esters as substrates. By contrast, γ-amino esters exhibit greater conformational diversity, so the effectiveness of the interaction is reduced, which apparently is responsible for the loss of enantioselectivity in the resolution process.

Design and synthesis of an orally active matrix metalloproteinase inhibitor

A series of 4-(4-phenoxy)benzoylamino-4-methoxymethyloxymethyl butyric acid hydroxamates, which were derived from l-glutamic acid, were synthesized and evaluated as matrix metalloproteinase inhibitors. Most of the compounds listed in Tables 1-3 exhibited