214610-12-5

Basic information

• Product Name: N-carbobenzyloxyindol-2-one
• Synonyms: N-carbobenzyloxyindol-2-one
• CAS NO: 214610-12-5
• Molecular Formula: C₁₆H₁₃NO₃
• Molecular Weight: 267
• Mol File: 214610-12-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-carbobenzyloxyindol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: N-carbobenzyloxyindol-2-one(214610-12-5)
• EPA Substance Registry System: N-carbobenzyloxyindol-2-one(214610-12-5)

Safety Data

• Hazardous Substances Data: 214610-12-5(Hazardous Substances Data)

Upstream product

• 6092-74-6 N-benzoyloxycarbonylphenylhydroxylamine 
• 91-56-5 indole-2,3-dione 
• 59-48-3 2-oxoindole 
• 214610-14-7 carbobenzyloxy-2-oxycarbobenzyloxyindol 
• 31139-36-3 dibenzyl dicarbonate 

Downstream Products

• 685089-25-2 1-(benzyloxycarbonyl)-3,3-bis(2-furoyloxymethyl)oxindole 
• 685089-19-4 1-(benzyloxycarbonyl)-3,3-bis(hydroxymethyl)oxindole 

Relevant articles and documents

Oxoarylation of ynamides with N-aryl hydroxamic acids

Ynamides are electron-rich alkynes with unique reactivities and act as flexible building blocks in organic synthesis. Therefore, the investigation for transformation of ynamides with exceptional selectivity and efficiency is attractive and interesting. He

New routes to oxindole derivatives

A new, practical synthesis of the antirheumatic oxindole derivative, tenidap, has been elaborated. The new approach has initiated studies on the mechanism of the acylation reactions of oxindoles. Methods have been developed for the synthesis of 1-[alkoxy(or aryloxy)carbonyl]- and 1,3-di[alkoxy(or aryloxy)carbonyl]oxindoles starting from oxindoles. The route designed for tenidap has provided a facile access to several analogues, too. On another front, new reaction conditions are described, which turn Wenkert's synthesis of 3-alkyloxindoles (by Raney nickel induced alkylation of oxindoles with alcohols) into a highly efficient synthetic tool. The method has been extended to the synthesis of 3-alkyloxindoles from isatins and to the preparation of 3-(ω-hydroxyalkyl)oxindoles from oxindoles and isatins. Springer-Verlag 2004.

Synthesis of 1,3-di[alkoxy(aryloxy)carbonyl]-2-oxo-2,3-dihydroindoles

Two protocols have been developed for the synthesis of 1,3-di[alkoxy(aryloxy)carbonyl]-2-oxo-2,3-dihydroindoles starting from the corresponding N,O-diacyl derivatives obtained by treatment of 2-oxindoles with chloroformic acid esters and triethylamine. Th

Studies on protection of oxindoles

Protection of amide nitrogen of oxindole and methyloxindole using Boc and Z-groups has been described. Sodium carbonate was found to be an effective base for these protections.