- Preparation method for clindamycin hydrochloride
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The invention specifically relates to a preparation method for clindamycin hydrochloride, belonging to the field of pharmaceutical chemistry. The preparation method comprises the following steps: (1) subjecting lincomycin hydrochloride and a Vilsmeier reagent to a chlorination reaction to obtain a chlorinated solution, wherein heating is gradually carried out in the process of the reaction; (2) cooling the chlorinated solution to 2 to 6 DEG C at a cooling rate of 14 to 20 DEG C/h, then carrying out a hydrolysis reaction in an aqueous solution of sodium hydroxide and then successively carrying out extraction, washing and concentration so as to obtain clindamycin free alkali; (3) subjecting the clindamycin free alkali and a saturated ethanol solution of hydrogen chloride to a salt formation reaction and carrying out crystallization, cooling, low-temperature crystallization and centrifugal washing so as to obtain a clindamycin hydrochloride alcohol adduct; and (4) subjecting the clindamycin hydrochloride alcohol adduct to dealcoholysis, crystallization, pumping filtration and drying so as to obtain clindamycin hydrochloride. Through optimization of the preparation method, yield is increased; impurity content is substantially reduced; and high-purity clindamycin hydrochloride is obtained.
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Paragraph 0018; 0019; 0020; 0021; 0022; 0023-0041
(2017/07/04)
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- Crystaline clindamycin free base
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A processes for preparing crystalline clindamycin free base is provided.
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- Process and device for producing liquid dosage formulations of medicinal compounds on demand from tablets and capsules
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The present invention provides a process for preparing liquid pharmaceutical formulations on demand from tablets and capsules.
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